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神経変性の原因となるタンパク質微粒子の形成と伝播機構

研究課題

戦略的な研究開発の推進 戦略的創造研究推進事業 CREST

体系的番号 JPMJCR18H3
DOI https://doi.org/10.52926/JPMJCR18H3

研究代表者

長谷川 成人  公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 分野長

研究期間 (年度) 2018 – 2023
概要細胞内で形成される異常タンパク質微粒子は、認知症や神経難病の病態形成・進行に関与します。本研究では、細胞内微粒子の形成・放出・伝播の過程に関わる分子群を網羅的に同定し、その分子機構の解明に挑みます。神経細胞内外の病原性タンパク質微粒子の新しい検出系の作出・病態進行を反映する生化学マーカーの同定・微粒子伝播の阻害による治療戦略の創成も目指します。
研究領域細胞外微粒子に起因する生命現象の解明とその制御に向けた基盤技術の創出

報告書

(2件)
  • 2023 事後評価書 ( PDF )   終了報告書 ( PDF )
  • 主な研究成果

    (20件)

すべて 2024

すべて 雑誌論文 (20件) (国際共著 5件、 査読あり 20件、 オープンアクセス 16件)

  • [雑誌論文] Clinicopathological study of dementia with grains presenting with parkinsonism compared with a typical case2024

    • 著者名
      Arakawa A, Goto R, Higashihara M, Hiroyoshi Y, Shioya A, Hara M, Orita M, Matsubara T, Sengoku R, Kameyama M, Tokumaru AM, Hasegawa M, Toda T, Iwata A, Murayama S, Saito Y.
    • 雑誌名

      Neuropathology

      巻: 44 号: 5 ページ: 376-387

    • 査読あり
  • [雑誌論文] Involvement of the glymphatic/meningeal lymphatic system in Alzheimer’s disease: insights into proteostasis and future directions2024

    • 著者名
      Kaoru Yamada, Takeshi Iwatsubo
    • 雑誌名

      Cellular and Molecular Life Sciences

      巻: 81 号: 1

    • 査読あり / オープンアクセス
  • [雑誌論文] The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis.2024

    • 著者名
      Zibold J, Lessard LER, Picard F, da Silva LG, Zadorozhna Y, Streichenberger N, Belotti E, Osseni A, Emerit A, Errazuriz-Cerda E, Michel-Calemard L, Menassa R, Coudert L, Wiessner M, Stucka R, Klopstock T, Simonetti F, Hutten S, Nonaka T, Hasegawa M, Strom TM, Bernard E, Ollagnon E, Urtizberea A, Dormann D, Petiot P, Schaeffer L, Senderek J, Leblanc P.
    • 雑誌名

      Brain

      巻: 147 号: 5 ページ: 1768-1783

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] An autopsy case of type A FTLD-TDP with a GRN mutation presenting with the logopenic variant of primary progressive aphasia at onset and with corticobasal syndrome subsequently2024

    • 著者名
      Takafumi Tomenaga, Shinobu Minatani, Hiroto Namba, Akitoshi Takeda, Takahito Yoshizaki, Joji Kawabe, Nazere Keyoumu, Hiroyuki Morino, Makoto Higuchi, Tomoyasu Matsubara, Hiroyuki Hatsuta, Masato Hasegawa, Shigeo Murayama, Yoshiaki Itoh
    • 雑誌名

      Neuropathology

    • 査読あり
  • [雑誌論文] Effects of local reduction of endogenous α-synuclein using antisense oligonucleotides on the fibril-induced propagation of pathology through the neural network in wild-type mice.2024

    • 著者名
      Tatsuhiko Sano, Tetsuya Nagata, Satoe Ebihara, Kie Yoshida-Tanaka, Ayako Nakamura, Asuka Sasaki, Aki Shimozawa, Hideki Mochizuki, Toshiki Uchihara, Masato Hasegawa, Takanori Yokota
    • 雑誌名

      Acta neuropathologica communications

      巻: 12 号: 1 ページ: 75-75

    • 査読あり / オープンアクセス
  • [雑誌論文] Tau filaments with the chronic traumatic encephalopathy fold in a case of vacuolar tauopathy with VCP mutation D395G.2024

    • 著者名
      Chao Qi, Ryota Kobayashi, Shinobu Kawakatsu, Fuyuki Kametani, Sjors H W Scheres, Michel Goedert, Masato Hasegawa
    • 雑誌名

      Acta neuropathologica

      巻: 147 号: 1 ページ: 86-86

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] Imaging α-synuclein pathologies in animal models and patients with Parkinson's and related diseases.2024

    • 著者名
      Hironobu Endo, Maiko Ono, Yuhei Takado, Kiwamu Matsuoka, Manami Takahashi, Kenji Tagai, Yuko Kataoka, Kosei Hirata, Keisuke Takahata, Chie Seki, Naomi Kokubo, Masayuki Fujinaga, Wakana Mori, Yuji Nagai, Koki Mimura, Katsushi Kumata, Tatsuya Kikuchi, Aki Shimozawa, Sushil K Mishra, Yoshiki Yamaguchi, Hiroshi Shimizu, Akiyoshi Kakita, Hiroyuki Takuwa, Hitoshi Shinotoh, Hitoshi Shimada, Yasuyuki Kimura, Masanori Ichise, Tetsuya Suhara, Takafumi Minamimoto, Naruhiko Sahara, Kazunori Kawamura, Ming-Rong Zhang, Masato Hasegawa, Makoto Higuchi
    • 雑誌名

      Neuron

    • 査読あり / オープンアクセス
  • [雑誌論文] Neurofibrillary tangle-predominant dementia followed by amyloid β pathology: a clinico-radio-pathological case providing insights into current disease-modifying therapeutic strategy.2024

    • 著者名
      Tomoyasu Matsubara, Kenji Ishii, Yoko Saito, Aya Midori Tokumaru, Akira Arakawa, Manato Hara, Masanori Kurihara, Renpei Sengoku, Kazutomi Kanemaru, Atsushi Iwata, Tomio Arai, Akinori Miyashita, Takeshi Ikeuchi, Masato Hasegawa, Shigeo Murayama, Yuko Saito
    • 雑誌名

      Acta neuropathologica communications

      巻: 12 号: 1 ページ: 98-98

    • 査読あり / オープンアクセス
  • [雑誌論文] Conventional magnetic resonance imaging key features for distinguishing pathologically confirmed corticobasal degeneration from its mimics: a retrospective analysis of the J-VAC study.2024

    • 著者名
      Keita Sakurai, Aya M Tokumaru, Mari Yoshida, Yuko Saito, Koichi Wakabayashi, Takashi Komori, Masato Hasegawa, Takeshi Ikeuchi, Yuichi Hayashi, Takayoshi Shimohata, Shigeo Murayama, Yasushi Iwasaki, Toshiki Uchihara, Motoko Sakai, Ichiro Yabe, Satoshi Tanikawa, Hiroshi Takigawa, Tadashi Adachi, Ritsuko Hanajima, Harutoshi Fujimura, Kentaro Hayashi, Keizo Sugaya, Kazuko Hasegawa, Terunori Sano, Masaki Takao, Osamu Yokota, Tomoko Miki, Michio Kobayashi, Nobutaka Arai, Takuya Ohkubo, Takanori Yokota, Keiko Mori, Masumi Ito, Chiho Ishida, Jiro Idezuka, Yasuko Toyoshima, Masato Kanazawa, Masashi Aoki, Takafumi Hasegawa, Hirohisa Watanabe, Atsushi Hashizume, Hisayoshi Niwa, Keizo Yasui, Keita Ito, Yukihiko Washimi, Akatsuki Kubota, Tatsushi Toda, Kenji Nakashima, Ikuko Aiba
    • 雑誌名

      Neuroradiology

    • 査読あり
  • [雑誌論文] Pure argyrophilic grain disease revisited: independent effects on limbic, neocortical, and striato-pallido-nigral degeneration and the development of dementia in a series with a low to moderate Braak stage2024

    • 著者名
      Osamu Yokota, Tomoko Miki, Hanae Nakashima-Yasuda, Hideki Ishizu, Takashi Haraguchi, Chikako Ikeda, Masato Hasegawa, Akinori Miyashita, Takeshi Ikeuchi, Naoto Nishikawa, Shintaro Takenoshita, Koichiro Sudo, Seishi Terada, Manabu Takaki
    • 雑誌名

      Acta Neuropathologica Communications

      巻: 12 号: 1

    • 査読あり / オープンアクセス
  • [雑誌論文] Chronic Neuronal Hyperexcitation Exacerbates Tau Propagation in a Mouse Model of Tauopathy2024

    • 著者名
      Itaru Nishida, Kaoru Yamada, Asami Sakamoto, Tomoko Wakabayashi, Takeshi Iwatsubo
    • 雑誌名

      International Journal of Molecular Sciences

      巻: 25 号: 16 ページ: 9004-9004

    • 査読あり / オープンアクセス
  • [雑誌論文] Long-standing preservation of levodopa response in progressive supranuclear palsy.2024

    • 著者名
      Terunori Sano, Masashi Mizutani, Tasuku Ishihara, Norikazu Hara, Akinori Miyashita, Takeshi Ikeuchi, Masato Hasegawa, Yuji Takahashi, Masaki Takao
    • 雑誌名

      Journal of the neurological sciences

      巻: 466 ページ: 123203-123203

    • 査読あり / オープンアクセス
  • [雑誌論文] Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP type C.2024

    • 著者名
      Diana Arseni, Takashi Nonaka, Max H Jacobsen, Alexey G Murzin, Laura Cracco, Sew Y Peak-Chew, Holly J Garringer, Ito Kawakami, Hisaomi Suzuki, Misumoto Onaya, Yuko Saito, Shigeo Murayama, Changiz Geula, Ruben Vidal, Kathy L Newell, Marsel Mesulam, Bernardino Ghetti, Masato Hasegawa, Benjamin Ryskeldi-Falcon
    • 雑誌名

      Nature

      巻: 634 号: 8034 ページ: 662-668

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] Analysis and comparison of post-translational modifications of α-synuclein filaments in multiple system atrophy and dementia with Lewy bodies.2024

    • 著者名
      Fuyuki Kametani, Marina Tahira, Masaki Takao, Tomoyasu Matsubara, Kazuko Hasegawa, Mari Yoshida, Yuko Saito, Shigeo Murayama, Masato Hasegawa
    • 雑誌名

      Scientific reports

      巻: 14 号: 1 ページ: 22892-22892

    • 査読あり / オープンアクセス
  • [雑誌論文] A novel peptide-based tau aggregation inhibitor as a potential therapeutic for Alzheimer's disease and other tauopathies.2024

    • 著者名
      Anthony Aggidis, George Devitt, Yongrui Zhang, Shreyasi Chatterjee, David Townsend, Nigel J Fullwood, Eva Ruiz Ortega, Airi Tarutani, Masato Hasegawa, Amber Cooper, Philip Williamson, Ayde Mendoza-Oliva, Marc I Diamond, Amritpal Mudher, David Allsop
    • 雑誌名

      Alzheimer's & dementia : the journal of the Alzheimer's Association

    • 査読あり / オープンアクセス / 国際共著
  • [雑誌論文] A case of argyrophilic grain disease with an initial clinical diagnosis of Parkinson's disease.2024

    • 著者名
      Akira Arakawa, Shigeo Murayama, Satoru Morimoto, Tomoyasu Matsubara, Renpei Sengoku, Masashi Kameyama, Aya M Tokumaru, Airi Tarutani, Masato Hasegawa, Atsushi Iwata, Tatsushi Toda, Yuko Saito
    • 雑誌名

      Journal of neurology

    • 査読あり / オープンアクセス
  • [雑誌論文] Dynamic aphasia as an early sign of corticobasal degeneration: Clinico-radio-pathological correlation.2024

    • 著者名
      Masanori Kurihara, Akira Arakawa, Aya Midori Tokumaru, Tomoyasu Matsubara, Hiroto Eguchi, Yasushi Shimo, Masato Hasegawa, Kazutomi Kanemaru, Katsuhiko Takeda, Atsushi Iwata, Shigeo Murayama, Yuko Saito
    • 雑誌名

      eNeurologicalSci

      巻: 37 ページ: 100526-100526

    • 査読あり / オープンアクセス
  • [雑誌論文] Cerebral hypoperfusion reduces tau accumulation.2024

    • 著者名
      Gheni G, Shinohara M, Masuda-Suzukake M, Shindo A, Watanabe A, Kawai K, Bu G, Tomimoto H, Hasegawa M, Sato N.
    • 雑誌名

      Ann Clin Transl Neurol.

      巻: 12 号: 1 ページ: 69-85

    • 査読あり / オープンアクセス
  • [雑誌論文] Motor involvement in frontotemporal lobar degeneration with <scp>TAR DNA</scp>‐binding protein of <scp>43?kDa</scp> type C2024

    • 著者名
      Rika Yamashita, Goichi Beck, Kazue Shigenobu, Airi Tarutani, Yuki Yonenobu, Makiko Kawai, Kohji Mori, Shinichiro Tahara, Yuto Satake, Yuko Saito, Eiichi Morii, Masato Hasegawa, Manabu Ikeda, Hideki Mochizuki, Shigeo Murayama
    • 雑誌名

      Neuropathology

    • 査読あり
  • [雑誌論文] Enhanced secretion of the amyotrophic lateral sclerosis ALS-associated misfolded TDP-43 mediated by the ER-ubiquitin specific peptidase USP19.2024

    • 著者名
      Picard F, Nonaka T, Belotti E, Osseni A, Errazuriz-Cerda E, Jost-Mousseau C, Bernard E, Conjard-Duplany A, Bohl D, Hasegawa M, Raoul C, Galli T, Schaeffer L, Leblanc P.
    • 雑誌名

      Cell Mol Life Sci.

      巻: 82 号: 1 ページ: 76

    • 査読あり / オープンアクセス / 国際共著

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JSTプロジェクトデータベース掲載開始日: 2019-08-01   JSTプロジェクトデータベース最終更新日: 2026-09-08  

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