複雑臓器制御系の数理的包括理解と超早期精密医療への挑戦

研究課題

体系的番号	JPMJMS2021
DOI	https://doi.org/10.52926/JPMJMS2021
研究代表者	合原一幸東京大学, 特別教授
研究期間 (年度)	2020 – 2025
概要	数理データ解析や数理モデル解析などの数理研究を、臓器間相互作用と制御に関する実験研究と統合する研究を実施します。それにより、2050年には、臓器間ネットワークを複雑臓器制御系として包括的に理解し、超早期精密医療へ応用することで、疾患の超早期予防システムが整備された社会の実現を目指します。
研究領域	(ムーンショット目標2)2050年までに、超早期に疾患の予測・予防をすることができる社会を実現

報告書

(5件)

主な研究成果
(110件)

すべて 2024

すべて雑誌論文 (110件) (国際共著 17件、査読あり 110件、オープンアクセス 106件)

[雑誌論文] Positive and Negative Feedback Regulation of the TGF-β1 Explains Two Equilibrium States in Skin Aging2024
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  Masatoshi Haga, Keita Iida, and Mariko Okada
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  iScience
  
  巻: 27 号: 5 ページ: 109708-1-109708-30
- DOI
  10.1016/j.isci.2024.109708
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[雑誌論文] Impact of time-history terms on reservoir dynamics and prediction accuracy in echo state networks2024
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  Yudai Ebato, Sou Nobukawa, Yusuke Sakemi, Haruhiko Nishimura, Takashi Kanamaru, Nina Sviridova, Kazuyuki Aihara
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  Scientific Reports
  
  巻: 14 号: 1 ページ: 8631_1-8631_13
- DOI
  10.1038/s41598-024-59143-y
- 査読あり / オープンアクセス
[雑誌論文] New Directions for Advanced Targeting Strategies of EGFR Signaling in Cancer2024
- 著者名
  Yue Zhou, Jun-Ichiro Takahashi, Hiroaki Sakurai
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  Biological and Pharmaceutical Bulletin
  
  巻: 47 号: 5 ページ: 895-903
- DOI
  10.1248/bpb.b23-00924
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[雑誌論文] Modeling and Predicting Individual Variation in COVID-19 Vaccine-Elicited Antibody Response in the General Population2024
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  Naotoshi Nakamura, Yurie Kobashi, Kwang Su Kim, Hyeongki Park, Yuta Tani, Yuzo Shimazu, Tianchen Zhao, Yoshitaka Nishikawa, Fumiya Omata, Moe Kawashima, Makoto Yoshida, Toshiki Abe, Yoshika Saito, Yuki Senoo, Saori Nonaka, Morihito Takita, Chika Yamamoto, Takeshi Kawamura, Akira Sugiyama, Aya Nakayama, Yudai Kaneko, Yong Dam Jeong, Daiki Tatematsu, Marwa Akao, Yoshitaka Sato, Shoya Iwanami, Yasuhisa Fujita, Masatoshi Wakui, Kazuyuki Aihara, Tatsuhiko Kodama, Kenji Shibuya, Shingo Iwami, and Masaharu Tsubokura
- 雑誌名
  
  PLOS Digital Health
  
  巻: 3 号: 5 ページ: e0000497-1-e0000497-23
- DOI
  10.1371/journal.pdig.0000497
- 査読あり / オープンアクセス / 国際共著
[雑誌論文] Revealing Cell-Cell Communication Pathways with Their Spatially Coupled Gene Programs2024
- 著者名
  Junchao Zhu, Hao Dai, Luonan Chen
- 雑誌名
  
  Briefings in Bioinformatics
  
  巻: 25 号: 3 ページ: bbae202_1-bbae202_12
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  10.1093/bib/bbae202
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[雑誌論文] Incorporation of likely future actions of agents into pseudo-gradient dynamics of noncooperative games2024
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  Yuyue Yan, Tomohisa Hayakawa
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  IEEE Transactions on Automatic Control
  
  巻: 69 号: 11 ページ: 7662 -7677
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  10.1109/TAC.2024.3397167
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[雑誌論文] Effects of pseudobulk and Gaussian noise on the application of the dynamical network biomarker theory to single-cell RNA-seq data2024
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  Shota Yonezawa, Takayuki Haruki, Keiichi Koizumi, Tomonobu M. Watanabe, Kuniya Abe, Yuhki Tada, Yuukou Horita
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  Journal of Advanced Simulation in Science and Engineering
  
  巻: 11 号: 1 ページ: 147-157
- DOI
  10.15748/jasse.11.147
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[雑誌論文] Identifying Key Regulatory Genes in Drug Resistance Acquisition: Modeling Pseudotime Trajectories of Breast Cancer Single-Cell Transcriptome2024
- 著者名
  Keita Iida and Mariko Okada
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  Cancers
  
  巻: 16 号: 10 ページ: 1884-1-1884-21
- DOI
  10.3390/cancers16101884
- 査読あり / オープンアクセス
[雑誌論文] Brugada Syndrome in Japan and Europe: a Genome-Wide Association Study Reveals Shared Genetic Architecture and New Risk Loci2024
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  Taisuke Ishikawa, Tatsuo Masuda, Tsuyoshi Hachiya, Christian Dina, Floriane Simonet, Yuki Nagata, Michael W T Tanck, Kyuto Sonehara, Charlotte Glinge, Rafik Tadros, Apichai Khongphatthanayothin, Tzu-Pin Lu, Chihiro Higuchi, Tadashi Nakajima, Kenshi Hayashi, Yoshiyasu Aizawa, Yukiko Nakano, Akihiko Nogami, Hiroshi Morita, Seiko Ohno, Takeshi Aiba, Christian Krijger Juarez, John Mauleekoonphairoj, Yong Poovorawan, Jean-Baptiste Gourraud, Wataru Shimizu, Vincent Probst, Minoru Horie, Arthur A M Wilde, Richard Redon, Jyh-Ming Jimmy Juang, Koonlawee Nademanee, Connie R Bezzina, Julien Barc, Toshihiro Tanaka, Yukinori Okada, Jean-Jacques Schott, and Naomasa Makita
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  European Heart Journal
  
  巻: 45 号: 26 ページ: 2320-2332
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  10.1093/eurheartj/ehae251
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[雑誌論文] Podocyte Pathogenic Bone Morphogenetic Protein-2 Pathway and Immune Cell Behaviors in Primary Membranous Nephropathy2024
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  Anxiang Cai, Yiwei Meng, Hang Zhou, Hong Cai, Xinghua Shao, Qin Wang, Yao Xu, Yin Zhou, Wenyan Zhou, Luonan Chen, Shan Mou
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  Advanced Science
  
  巻: 11 号: 29 ページ: e2404151_1-e2404151_18
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  10.1002/advs.202404151
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[雑誌論文] Multi-Modal Domain Adaptation for Revealing Spatial Functional Landscape from Spatially Resolved Transcriptomics2024
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  Lequn Wang, Yaofeng Hu, Kai Xiao, Chuanchao Zhang, Qianqian Shi, Luonan Chen
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  Briefings in Bioinformatics
  
  巻: 25 号: 4 ページ: bbae257_1-bbae257_13
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  10.1093/bib/bbae257
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[雑誌論文] Reliability of energy landscape analysis of resting-state functional MRI data2024
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  Pitambar Khanra, Johan Nakuci, Sarah Muldoon, Takamitsu Watanabe, and Naoki Masuda
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  European Journal of Neuroscience
  
  巻: 60 号: 3 ページ: 4265-4290
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  10.1111/ejn.16390
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[雑誌論文] Evolutionary game dynamics with environmental feedback in a network with two communities2024
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  Katherine Betz, Feng Fu, and Naoki Masuda
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  Bulletin of Mathematical Biology
  
  巻: 86 号: 84 ページ: 84-1-84-45
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  10.1007/s11538-024-01310-3
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[雑誌論文] Physical and Psychosocial Factors Associated with Fatigue in Individuals with 22q11.2 Deletion Syndrome2024
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  Psychiatry and Clinical Neurosciences Reports
  
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[雑誌論文] Body Mass Index Stratification Optimizes Polygenic Prediction of Type 2 Diabetes in Cross-Biobank Analyses2024
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  Takafumi Ojima, Shinichi Namba, Ken Suzuki, Kenichi Yamamoto, Kyuto Sonehara, Akira Narita, the Tohoku Medical Megabank Project Study Group, the Biobank Japan Project, Yoichiro Kamatani, Gen Tamiya, Masayuki Yamamoto, Toshimasa Yamauchi, Takashi Kadowaki, and Yukinori Okada
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  Nature Genetics
  
  巻: 56 号: 6 ページ: 1100-1109
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  10.1038/s41588-024-01782-y
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[雑誌論文] Dissecting Tumor Microenvironment from Spatially Resolved Transcriptomics Data by Heterogeneous Graph Learning2024
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  Chunman Zuo, Junjie Xia, Luonan Chen
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  Nature Communications
  
  巻: 15 号: 1 ページ: 5057_1-5057_18
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  10.1038/s41467-024-49171-7
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[雑誌論文] An Energy Landscape Approach Reveals the Potential Key Bacteria Contributing to the Development of Inflammatory Bowel Disease2024
- 著者名
  Kaiyang Zhang and Shinji Nakaoka
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  PLOS ONE
  
  巻: 19 号: 6 ページ: e0302151-1-e0302151-19
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  10.1371/journal.pone.0302151
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[雑誌論文] Abnormal Resting-State Hyperconnectivity in Schizophrenia: A Whole-Head Near-Infrared Spectroscopy Study2024
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  Eisuke Sakakibara, Yoshihiro Satomura, Jun Matsuoka, Shinsuke Koike, Naohiro Okada, Hanako Sakurada, Mika Yamagishi, Norito Kawakami, Kiyoto Kasai
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  Schizophrenia Research
  
  巻: 270 号: - ページ: 121-128
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[雑誌論文] Psychotic Experiences and Dissociation in Adolescents: Within-Person Analysis in the Tokyo Teen Cohort2024
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  Rin Minami, Syudo Yamasaki, Tomoki Kiyono, Riki Tanaka, Sho Kanata, Shinya Fujikawa, Satoshi Usami, Daniel Stanyon, Atsushi Nishida, Kiyoto Kasai, Shuntaro Ando
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  Schizophrenia Research
  
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[雑誌論文] Investigating the Differential Impact of Short- and Long-Term Informal Caregiving on Mental Health Across Adolescence: Data From the Tokyo Teen Cohort2024
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  Daniel Stanyon, Miharu Nakanishi, Syudo Yamasaki, Mitsuhiro Miyashita, Satoshi Yamaguchi, Kaori Baba, Naomi Nakajima, Junko Niimura, Jordan DeVylder, Mariko Hiraiwa-Hasegawa, Shuntaro Ando, Kiyoto Kasai, and Atsushi Nishida
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  Journal of Adolescent Health
  
  巻: 75 号: 4 ページ: 642-649
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  10.1016/j.jadohealth.2024.06.005
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[雑誌論文] Atypical Intrinsic Neural Timescale in the Left Angular Gyrus in Alzheimer’s Disease2024
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  Shota A Murai, Tatsuo Mano, Jerome N Sanes, and Takamitsu Watanabe
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  Brain Communications
  
  巻: 6 号: 4 ページ: fcae199-1-fcae199-14
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  10.1093/braincomms/fcae199
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[雑誌論文] Common and Rare Genetic Variants Predisposing Females to Unexplained Recurrent Pregnancy Loss2024
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  Kyuto Sonehara, Yoshitaka Yano, Tatsuhiko Naito, Shinobu Goto, Hiroyuki Yoshihara, Takahiro Otani, Fumiko Ozawa, Tamao Kitaori; Biobank Japan Project; Koichi Matsuda, Takashi Nishiyama, Yukinori Okada, and Mayumi Sugiura-Ogasawara
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  Nature Communications
  
  巻: 15 号: 1 ページ: 5744_1-5744_9
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  10.1038/s41467-024-49993-5
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[雑誌論文] Frontal Pole-Precuneus Connectivity Is Associated with a Discrepancy Between Self-Rated and Observer-Rated Depression Severity in Mood Disorders: A Resting-State Functional Magnetic Resonance Imaging Study2024
- 著者名
  Shintaro Kawakami, Naohiro Okada, Yoshihiro Satomura, Eimu Shoji, Shunsuke Mori, Masahiro Kiyota, Favour Omileke, Yu Hamamoto, Susumu Morita, Daisuke Koshiyama, Mika Yamagishi, Eisuke Sakakibara, Shinsuke Koike, Kiyoto Kasai
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  Cerebral Cortex
  
  巻: 34 号: 7 ページ: bhae284_1-bhae284_10
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  10.1093/cercor/bhae284
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[雑誌論文] Lower plasma betaine levels in men at clinical high risk for psychosis: Findings from a metabolomics investigation2024
- 著者名
  Tatsuro Asai , Tempei Ikegame , Yoshihiro Satomura, Eureka Kumagai, Takuto Minami, Susumu Morita, Masahiro Kiyota, Eimu Shoji, Zhilei Zhao, Akiko Kanehara, Mariko Tada, Naohiro Okada, Shinsuke Koike, Miki Bundo, Kazuya Iwamoto, Kiyoto Kasai, Seiichiro Jinde
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  Schizophrenia Research
  
  巻: 271 号: - ページ: 281-282
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  10.1016/j.schres.2024.07.051
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[雑誌論文] The Need for Data Standardization and Research Data Management Infrastructure to Promote the Use of Real-World Data2024
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  Satoshi Ueno, Yusuke Komiyama, Mariko Doi, Keika Hoshi
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  Journal of the Society for Clinical Data Management
  
  巻: 5 号: 2 ページ: ---
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  10.47912/jscdm.210
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[雑誌論文] Temporal scaling theory for bursty time series with clusters of arbitrarily many events2024
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  Hang-Hyun Jo, Tibebe Birhanu, Naoki Masuda
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  Chaos
  
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  10.1063/5.0219561
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[雑誌論文] Role of immune cells in the establishment of implantation and maintenance of pregnancy and immunomodulatory therapies for patients with repeated implantation failure and recurrent pregnancy loss2024
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  Shigeru Saito
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  Reproductive Medicine and Biology
  
  巻: 23 号: 1 ページ: e12600-1-e12600-12
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  10.1002/rmb2.12600
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[雑誌論文] Correlations of brain structure with the social behavior of 15q11-13 duplication mice, an animal model of autism2024
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  Zhilei Zhao, Naohiro Okada, Sho Yagishita, Noriaki Yahata, Nobuhiro Nitta, Sayaka Shibata, Yoshifumi Abe, Susumu Morita, Eureka Kumagai, Kenji F Tanaka, Tetsuya Suhara, Toru Takumi, Kiyoto Kasai, Seiichiro Jinde
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  Neuroscience Research
  
  巻: 209 号: - ページ: 42-49
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  10.1016/j.neures.2024.07.009
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[雑誌論文] Primary Aldosteronism and Risk of Cardiovascular Outcomes: Genome‐Wide Association and Mendelian Randomization Study2024
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  Kosuke Inoue, Tatsuhiko Naito, Ryosuke Fuji, Kyuto Sonehara, Kenichi Yamamoto, Ryuta Baba, Takaya Kodama, Yu Otagaki, Akira Okada, Kiyotaka Itcho, Kazuhiro Kobuke, Haruya Ohno; BioBank Japan; Takayuki Morisaki, Noboru Hattori, Atsushi Goto, Tetsuo Nishikawa, Kenji Oki, and Yukinori Okada
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  Journal of the American Heart Association
  
  巻: 13 号: 15 ページ: e034180_1-e034180_10
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  10.1161/JAHA.123.034180
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[雑誌論文] Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues2024
- 著者名
  Yoshihiko Tomofuji, Ryuya Edahiro, Kyuto Sonehara, Yuya Shirai, Kian Hong Kock, Qingbo S Wang, Shinichi Namba, Jonathan Moody, Yoshinari Ando, Akari Suzuki, Tomohiro Yata, Kotaro Ogawa, Tatsuhiko Naito, Ho Namkoong, Quy Xiao Xuan Lin, Eliora Violain Buyamin, Le Min Tan, Radhika Sonthalia, Kyung Yeon Han, Hiromu Tanaka, Ho Lee; Asian Immune Diversity Atlas Network, Japan COVID-19 Task Force, The BioBank Japan Project; Tatsusada Okuno, Boxiang Liu, Koichi Matsuda, Koichi Fukunaga, Hideki Mochizuki, Woong-Yang Park, Kazuhiko Yamamoto, Chung-Chau Hon, Jay W Shin, Shyam Prabhakar, Atsushi Kumanogoh, and Yukinori Okada
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  Cell Genomics
  
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  10.1016/j.xgen.2024.100625
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[雑誌論文] Re-stabilizing Large-Scale Network Systems Using High-Dimension Low-Sample-Size Data Analysis2024
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  Xun Shen, Hampei Sasahara, Jun-ichi Imura, Makito Oku, Kazuyuki Aihara
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  IEEE Transactions on Emerging Topics in Computational Intelligence
  
  巻: 9 号: 2 ページ: 1638-1649
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  10.1109/TETCI.2024.3442824
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[雑誌論文] Large-scale cross-trait genetic analysis highlights shared genetic backgrounds of autoimmune diseases2024
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  Yuji Yamamoto, Yuya Shirai, Ryuya Edahiro, Atsushi Kumanogoh, and Yukinori Okada
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  Immunological Medicine
  
  巻: 48 号: 1 ページ: 1-10
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  10.1080/25785826.2024.2394258
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[雑誌論文] Modelling the Effectiveness of an Isolation Strategy for Managing Mpox Outbreaks with Variable Infectiousness Profiles2024
- 著者名
  Yong Dam Jeong, William S Hart, Robin N Thompson, Masahiro Ishikane, Takara Nishiyama, Hyeongki Park, Noriko Iwamoto, Ayana Sakurai, Michiyo Suzuki, Kazuyuki Aihara, Koichi Watashi, Eline Op de Coul, Norio Ohmagari, Jacco Wallinga, Shingo Iwami, Fuminari Miura
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  Nature Communications
  
  巻: 15 号: 1 ページ: 7112_1-7112_12
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  10.1038/s41467-024-51143-w
- 査読あり / オープンアクセス / 国際共著
[雑誌論文] Applying Coherent Ising Machines for Enhancing Communication Efficiency in Large-Scale UAV-Aided Networks2024
- 著者名
  Tsukumo Fujita, Aohan Li, Quang Vinh Do, Teppei Otsuka, Seon-Geun Jeong, Won-Joo Hwang, Hiroki Takesue, Kensuke Inaba, Kazuyuki Aihara, and Mikio Hasegawa
- 雑誌名
  
  IEEE Access
  
  巻: 12 号: - ページ: 136011-136024
- DOI
  10.1109/ACCESS.2024.3450539
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[雑誌論文] Constant-selection evolutionary dynamics on weighted networks2024
- 著者名
  Jnanajyoti Bhaumik and Naoki Masuda
- 雑誌名
  
  Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences
  
  巻: 480 号: 2296 ページ: 20240223_1-20240223_18
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  10.1098/rspa.2024.0223
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[雑誌論文] Clarinet plots: Alternative to violin plots to display zero-inflated distribution of scRNA-seq data2024
- 著者名
  Makito Oku
- 雑誌名
  
  IPSJ Transactions on Bioinformatics
  
  巻: 17 号: - ページ: 48-54
- DOI
  10.2197/ipsjtbio.17.48
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[雑誌論文] Topology of Nash Equilibrium Set with Quadratic Vector Payoff Functions2024
- 著者名
  Zehui Guo and Tomohisa Hayakawa
- 雑誌名
  
  Proceedings of 2024 American Control Conference (ACC)
  
  巻: - 号: - ページ: 845-850
- DOI
  10.23919/ACC60939.2024.10644643
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[雑誌論文] Designing Network Topologies of Multiple Reservoir Echo State Networks: A Genetic Algorithm Based Approach2024
- 著者名
  Ziqiang Li, Kantaro Fujiwara, Gouhei Tanaka
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  Proceedings of 2024 International Joint Conference on Neural Networks (IJCNN)
  
  巻: - 号: - ページ: ---
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  10.1109/IJCNN60899.2024.10650945
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[雑誌論文] Can Timing-Based Backpropagation Overcome Single-Spike Restrictions in Spiking Neural Networks?2024
- 著者名
  Kakei Yamamoto, Yusuke Sakemi, and Kazuyuki Aihara
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  Proceedings of 2024 International Joint Conference on Neural Networks (IJCNN)
  
  巻: - 号: - ページ: ---
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  10.1109/IJCNN60899.2024.10651135
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[雑誌論文] Clonal landscape of autoantibody-secreting plasmablasts in COVID-19 patients2024
- 著者名
  Shuhei Sakakibara, Yu-Chen Liu, Masakazu Ishikawa, Ryuya Edahiro, Yuya Shirai, Soichiro Haruna, Marwa Ali El Hussien, Zichang Xu, Songling Li, Yuta Yamaguchi, Teruaki Murakami, Takayoshi Morita, Yasuhiro Kato, Haruhiko Hirata, Yoshito Takeda, Fuminori Sugihara, Yoko Naito, Daisuke Motooka, Chao-Yuan Tsai, Chikako Ono, Yoshiharu Matsuura, James B Wing, Hisatake Matsumoto, Hiroshi Ogura, Masato Okada, Atsushi Kumanogoh, Yukinari Okada, Daron M Standley, Hitoshi Kikutani, and Daisuke Okuzaki
- 雑誌名
  
  Life Science Alliance
  
  巻: 7 号: 12 ページ: e202402774-1-e202402774-18
- DOI
  10.26508/lsa.202402774
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[雑誌論文] Revealing Functions of Extra-large Excitatory Postsynaptic Potentials: Insights from Dynamical Characteristics of Reservoir Computing with Spiking Neural Networks2024
- 著者名
  Asato Fujimoto, Sou Nobukawa, Yusuke Sakemi, Yoshiho Ikeuchi, and Kazuyuki Aihara
- 雑誌名
  
  Proceedings of the 33rd International Conference on Artificial Neural Networks (ICANN2024)
  
  巻: - 号: - ページ: 151-165
- DOI
  10.1007/978-3-031-72341-4_11
- 査読あり / オープンアクセス
[雑誌論文] Machine learning reveals heterogeneous associations between environmental factors and cardiometabolic diseases across polygenic risk scores2024
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  Tatsuhiko Naito, Kosuke Inoue, Shinichi Namba, Kyuto Sonehara, Ken Suzuki; BioBank Japan; Koichi Matsuda, Naoki Kondo, Tatsushi Toda, Toshimasa Yamauchi, Takashi Kadowaki, and Yukinori Okada
- 雑誌名
  
  Communications Medicine
  
  巻: 4 号: 1 ページ: 181-1-181-12
- DOI
  10.1038/s43856-024-00596-7
- 査読あり / オープンアクセス
[雑誌論文] Functional landscape of genome-wide postzygotic somatic mutations between monozygotic twins2024
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  Kenichi Yamamoto, Yoko Lee, Tatsuo Masuda, Keiichi Ozono, Yoshinori Iwatani, Mikio Watanabe, Yukinori Okada, and Norio Sakai
- 雑誌名
  
  DNA Research
  
  巻: 31 号: 5 ページ: dsae028-1-dsae028-9
- DOI
  10.1093/dnares/dsae028
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[雑誌論文] Statistically and functionally fine-mapped blood eQTLs and pQTLs from 1,405 humans reveal distinct regulation patterns and disease relevance2024
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  Qingbo S Wang, Takanori Hasegawa, Ho Namkoong, Ryunosuke Saiki, Ryuya Edahiro, Kyuto Sonehara, Hiromu Tanaka, Shuhei Azekawa, Shotaro Chubachi, Yugo Takahashi, Saori Sakaue, Shinichi Namba, Kenichi Yamamoto, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hideki Makishima, Yasuhito Nannya, Zicong Zhang, Rika Tsujikawa, Ryuji Koike, Tomomi Takano, Makoto Ishii, Akinori Kimura, Fumitaka Inoue, Takanori Kanai, Koichi Fukunaga, Seishi Ogawa, Seiya Imoto, Satoru Miyano, Yukinori Okada; Japan COVID-19 Task Force
- 雑誌名
  
  Nature Genetics
  
  巻: Vol.56 号: No.10 ページ: 2054-2067
- DOI
  10.1038/s41588-024-01896-3
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[雑誌論文] Development of a method for the imputation of the multi-allelic serotonin-transporter-linked polymorphic region (5-HTTLPR) in the Japanese population2024
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  Yutaro Yanagida, Izumi Naka, Yutaka Nakachi, Tempei Ikegame, Kiyoto Kasai, Naoto Kajitani, Minoru Takebayashi, Miki Bundo, Jun Ohashi, Kazuya Iwamoto
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  Journal of Human Genetics
  
  巻: 70 号: 1 ページ: 41-45
- DOI
  10.1038/s10038-024-01296-9
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[雑誌論文] Low-dose aspirin and heparin treatment improves pregnancy outcome in recurrent pregnancy loss women with anti-β2-glycoprotein I/HLA-DR autoantibodies: a prospective, multicenter, observational study2024
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  Kenji Tanimura, Shigeru Saito, Sayaka Tsuda, Yosuke Ono, Masashi Deguchi, Takeshi Nagamatsu, Tomoyuki Fujii, Mikiya Nakatsuka, Gen Kobashi, Hisashi Arase, Hideto Yamada
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  Frontiers in Immunology
  
  巻: 15 号: - ページ: 1445852-1-1445852-13
- DOI
  10.3389/fimmu.2024.1445852
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[雑誌論文] Generalizable and transportable resting-state neural signatures characterized by functional networks, neurotransmitters, and clinical symptoms in autism2024
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  Takashi Itahashi, Ayumu Yamashita, Yuji Takahara, Noriaki Yahata, Yuta Y Aoki, Junya Fujino, Yujiro Yoshihara, Motoaki Nakamura, Ryuta Aoki, Tsukasa Okimura, Haruhisa Ohta, Yuki Sakai, Masahiro Takamura, Naho Ichikawa, Go Okada, Naohiro Okada, Kiyoto Kasai, Saori C Tanaka, Hiroshi Imamizu, Nobumasa Kato, Yasumasa Okamoto, Hidehiko Takahashi, Mitsuo Kawato, Okito Yamashita, Ryu-Ichiro Hashimoto
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  Molecular Psychiatry
  
  巻: 30 号: - ページ: 1466-1478
- DOI
  10.1038/s41380-024-02759-3
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[雑誌論文] Fixation dynamics on multilayer networks2024
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  Ruodan Liu and Naoki Masuda
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  SIAM Journal on Applied Mathematics
  
  巻: 84 号: 5 ページ: 2028-2050
- DOI
  10.1137/23M1620144
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[雑誌論文] Deletion of platelet-derived growth factor receptor β suppresses tumorigenesis in metabolic dysfunction-associated steatohepatitis (MASH) mice with diabetes2024
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  Tsutomu Wada, Yuki Takeda, Akira Okekawa, Go Komatsu, Yuichi Iwasa, Yasuhiro Onogi, Ichiro Takasaki, Takeru Hamashima, Masakiyo Sasahara, Hiroshi Tsuneki, Toshiyasu Sasaoka
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  Scientific Reports
  
  巻: 14 号: 1 ページ: 23829-1-23829-12
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  10.1038/s41598-024-75713-6
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[雑誌論文] Inconsistent Embryo Selection Across Polygenic Score Methods2024
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  Shinichi Namba, Masato Akiyama, Haruka Hamanoue, Kazuto Kato, Minae Kawashima, Itaru Kushima, Koichi Matsuda, Masahiro Nakatochi, Soichi Ogishima, Kyuto Sonehara, Ken Suzuki, Atsushi Takata, Gen Tamiya, Chizu Tanikawa, Kenichi Yamamoto, Natsuko Yamamoto, The BioBank Japan Project, Norio Ozaki, and Yukinori Okada
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  Nature Human Behaviour
  
  巻: Vol.8 号: No.12 ページ: 2264-2267
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  10.1038/s41562-024-02019-y
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[雑誌論文] Dual decoding of cell types and gene expression in spatial transcriptomics with PANDA2024
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  Meng-Guo Wang, Luonan Chen, Xiao-Fei Zhang
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  Nucleic Acids Research
  
  巻: 52 号: 20 ページ: 12173-12190
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  10.1093/nar/gkae876
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[雑誌論文] Online landmark replacement for out-of-sample dimensionality reduction methods2024
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  Chanon Thongprayoon, Naoki Masuda
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  Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences
  
  巻: 480 号: 2300 ページ: 20230966-1-20230966-29
- DOI
  10.1098/rspa.2023.0966
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[雑誌論文] Reconstructing Molecular Networks by Causal Diffusion Do-Calculus Analysis with Deep Learning2024
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  Jiachen Wang, Yuelei Zhang, Luonan Chen, Xiaoping Liu
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  Advanced Science
  
  巻: 11 号: 46 ページ: e2409170-1-e2409170-14
- DOI
  10.1002/advs.202409170
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[雑誌論文] Across Trials vs Subjects vs Contexts: A Multi-Reservoir Computing Approach for EEG Variations in Emotion Recognition2024
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  Anubhav, Kantaro Fujiwara
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  Proc ICMI'24
  
  巻: - 号: - ページ: 518-525
- DOI
  10.1145/3678957.3685730
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[雑誌論文] A Parrondo paradox in susceptible-infectious-susceptible dynamics over periodic temporal networks2024
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  Maisha Islam Sejunti, Dane Taylor, Naoki Masuda
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  Mathematical Biosciences
  
  巻: 378 号: - ページ: 109336-1-109336-13
- DOI
  10.1016/j.mbs.2024.109336
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[雑誌論文] From the Laboratory to the Real-World: The Role of Mismatch Negativity in Psychosis2024
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  Mariko Tada, Sho Yagishita, Takanori Uka, Ryoichi Nishimura, Taiki Kishigami, Kenji Kirihara, Daisuke Koshiyama, Kaori Usui, Mao Fujioka, Tsuyoshi Araki, Kiyoto Kasai
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  Clinical EEG and Neuroscience
  
  巻: 56 号: 1 ページ: 60-71
- DOI
  10.1177/15500594241294188
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[雑誌論文] Integrative study of lung cancer adeno-to-squamous transition in EGFR TKI resistance identifies RAPGEF3 as a therapeutic target2024
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  Hua Wang, Shijie Tang, Qibiao Wu, Yayi He, Weikang Zhu, Xinyun Xie, Zhen Qin, Xue Wang, Shiyu Zhou, Shun Yao, Xiaoling Xu, Chenchen Guo, Xinyuan Tong, Shuo Han, Yueh-Hung Chou, Yong Wang, Kwok-Kin Wong, Cai-Guang Yang, Luonan Chen, Liang Hu, Hongbin Ji
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  National Science Review
  
  巻: 11 号: 12 ページ: nwae392-1-nwae392-20
- DOI
  10.1093/nsr/nwae392
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[雑誌論文] Genetic legacy of ancient hunter-gatherer Jomon in Japanese populations2024
- 著者名
  Kenichi Yamamoto, Shinichi Namba, Kyuto Sonehara, Ken Suzuki, Saori Sakaue, Niall P Cooke, Shinichi Higashiue, Shuzo Kobayashi, Hisaaki Afuso, Kosho Matsuura, Yojiro Mitsumoto, Yasuhiko Fujita, Torao Tokuda; Biobank Japan Project; Koichi Matsuda, Takashi Gakuhari, Toshimasa Yamauchi, Takashi Kadowaki, Shigeki Nakagome, Yukinori Okada
- 雑誌名
  
  Nature Communications
  
  巻: 15 号: 1 ページ: 9780-1-9780-15
- DOI
  10.1038/s41467-024-54052-0
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[雑誌論文] JAK/STAT Signaling Maintains an Intermediate Cell Population during Prostate Basal Cell Fate Determination2024
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  Wangxin Guo, Xiaoyu Zhang, Lin Li, Pengfei Shao, Chao Liang, Hongjiong Zhang, Kuo Liu, Shuoming Wang, Yunyi Peng, Jun Luo, Yi Ju, Angelo M. De Marzo, Chen Yu, Luonan Chen, Bin Zhou, and Dong Gao
- 雑誌名
  
  Nature Genetics
  
  巻: 56 号: 12 ページ: 2776-2789
- DOI
  10.1038/s41588-024-01979-1
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[雑誌論文] Epigenetic characterization of adult rhesus monkey spermatogonial stem cells identifies key regulators of stem cell homeostasis2024
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  Rui Bi, Lin-Nuo Pan, Hao Dai, Chunli Sun, Cong Li, Hui-Juan Lin, Lan-Ping Xie, Huai-Xiao Ma, Lin Li, Heng Xie, Kun Guo, Chun-Hui Hou, Yong-Gang Yao, Luo-Nan Chen, Ping Zheng
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  Nucleic Acids Research
  
  巻: 52 号: 22 ページ: 13644-13664
- DOI
  10.1093/nar/gkae1013
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[雑誌論文] Indigenous gut microbiota constitutively drive release of ciliary neurotrophic factor from mucosal enteric glia to maintain the homeostasis of enteric neural circuits2024
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  Ryo Kato, Takeshi Yamamoto, Hanako Ogata, Kana Miyata, Shusaku Hayashi, Michael D. Gershon, Makoto Kadowaki
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  Frontiers in Immunology
  
  巻: 15 号: - ページ: 1372670-1-1372670-15
- DOI
  10.3389/fimmu.2024.1372670
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[雑誌論文] Multi-Omics With Dynamic Network Biomarker Algorithm Prefigures Organ-Specific Metastasis of Lung Adenocarcinoma2024
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  Xiaoshen Zhang, Kai Xiao, Yaokai Wen, Fengying Wu, Guanghui Gao, Luonan Chen, and Caicun Zhou
- 雑誌名
  
  Nature Communications
  
  巻: 15 号: 1 ページ: 9855-1 -9855-19
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  10.1038/s41467-024-53849-3
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[雑誌論文] Leveraging genome-wide association studies to better understand the etiology of cancers2024
- 著者名
  Kyuto Sonehara, Yukinori Okada
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  Cancer Science
  
  巻: 116 号: 2 ページ: 288-296
- DOI
  10.1111/cas.16402
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[雑誌論文] Quantification of the synergistic inhibitory effects of an oncolytic herpes virus plus paclitaxel on anaplastic thyroid cancer cells2024
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  Anna Park, Jong Hyuk Byun, Il Hyo Jung, Shingo Iwami, Kwang Su Kim
- 雑誌名
  
  Complexity
  
  巻: 2024 号: - ページ: 3899849-1-3899849-9
- DOI
  10.1155/cplx/3899849
- 査読あり / オープンアクセス / 国際共著
[雑誌論文] MCGAE: Unraveling Tumor Invasion through Integrated Multimodal Spatial Transcriptomics2024
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  Yiwen Yang, Chengming Zhang, Zhaonan Liu, Kazuyuki Aihara, Chuanchao Zhang, Luonan Chen, Wu Wei
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  Briefings in Bioinformatics
  
  巻: 26 号: 1 ページ: bbae608-1-bbae608-13
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  10.1093/bib/bbae608
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[雑誌論文] Increased structural covariance of cortical measures in individuals with an at-risk mental state2024
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  Daiki Sasabayashi, Sakiko Tsugawa, Shinichiro Nakajima, Tsutomu Takahashi, Yoichiro Takayanagi, Shinsuke Koike, Naoyuki Katagiri, Masahiro Katsura, Atsushi Furuichi, Yuko Mizukami, Shimako Nishiyama, Haruko Kobayashi, Yusuke Yuasa, Naohisa Tsujino, Atsushi Sakuma, Noriyuki Ohmuro, Yutaro Sato, Kazuho Tomimoto, Naohiro Okada, Mariko Tada, Motomu Suga, Norihide Maikusa, Eric Plitman, Cassandra M J Wannan, Andrew Zalesky, Mallar Chakravarty, Kyo Noguchi, Hidenori Yamasue, Kazunori Matsumoto, Takahiro Nemoto, Hiroaki Tomita, Masafumi Mizuno, Kiyoto Kasai, Michio Suzuki
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  Progress in Neuro-Psychopharmacology and Biological Psychiatry
  
  巻: 136 号: - ページ: 111197-1-111197-9
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  10.1016/j.pnpbp.2024.111197
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[雑誌論文] Dynamic Tuning of Neural Stability for Cognitive Control2024
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  Muyuan Xu, Takayuki Hosokawa, Ken-Ichiro Tsutsui, and Kazuyuki Aihara
- 雑誌名
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  巻: 121 号: 49 ページ: e2409487121-1 -e2409487121-8
- DOI
  10.1073/pnas.2409487121
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[雑誌論文] Preferential neurogenesis of nitrergic neurons in the myenteric plexus of the DSS-induced colitis mouse colon causes colonic dysmotility in colitis2024
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  Kana Miyata, Takeshi Yamamoto, Ryo Kato, Shusaku Hayashi, Makoto Kadowaki
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  American Journal of Physiology-Gastrointestinal and Liver Physiology
  
  巻: 329 号: 1 ページ: G17-G28
- DOI
  10.1152/ajpgi.00219.2023
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[雑誌論文] Fast-Slow Analysis and Bifurcations in the Generation of the Early Afterdepolarization Phenomenon in a Realistic Mathematical Human Ventricular Myocyte Model2024
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  Hiroyuki Kitajima, Toru Yazawa, and Roberto Barrio
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  Chaos
  
  巻: 34 号: 12 ページ: 123108-1-123108-13
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  10.1063/5.0230834
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[雑誌論文] Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases2024
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  Chi Tian, Yuntian Zhang, Yihan Tong, Kian Hong Kock, Donald Yuhui Sim, Fei Liu, Jiaqi Dong, Zhixuan Jing, Wenjing Wang, Junbin Gao, Le Min Tan, Kyung Yeon Han, Yoshihiko Tomofuji, Masahiro Nakano, Eliora Violain Buyamin, Radhika Sonthalia, Yoshinari Ando, Hiroaki Hatano, Kyuto Sonehara; Asian Immune Diversity Atlas Network; Xin Jin, Marie Loh, John Chambers, Chung-Chau Hon, Murim Choi, Jong-Eun Park, Kazuyoshi Ishigaki, Tomohisa Okamura, Keishi Fujio, Yukinori Okada, Woong-Yang Park, Jay W Shin, Xavier Roca, Shyam Prabhakar, Boxiang Liu
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  Nature Genetics
  
  巻: 56 号: 12 ページ: 2739-2752
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  10.1038/s41588-024-02019-8
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[雑誌論文] Study on the Data Reduction Effect on Dynamical Properties of Imaging Photoplethysmogram2024
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  Kodai Koga, Nina Sviridova
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  Proceedings of the 2024 International Symposium on Nonlinear Theory and Its Applications (NOLTA2024)
  
  巻: - 号: - ページ: 81-84
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[雑誌論文] Dependence of Imaging Photoplethysmogram Dynamical Properties on Measurement Distance2024
- 著者名
  Hayato Sato, Nina Sviridova
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  Proceedings of the 2024 International Symposium on Nonlinear Theory and Its Applications (NOLTA2024)
  
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[雑誌論文] A Study on Coupling Models of Nonlinear Oscillator Networks to Realize Decentralized TDMA2024
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  Takuma Osada, Hiroyuki Yasuda, Song-Ju Kim, Maki Arai and Mikio Hasegawa
- 雑誌名
  
  Proceedings of the 2024 International Symposium on Nonlinear Theory and Its Applications (NOLTA2024)
  
  巻: - 号: - ページ: 157-160
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[雑誌論文] A Study on Parameter Dependency of Coupling Function in Decentralized TDMA Based on the Kuramoto Model2024
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  Hiroyuki Yasuda, Takuma Osada, Mikio Hasegawa, and Kazuyuki Aihara
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  Proceedings of the 2024 International Symposium on Nonlinear Theory and Its Applications (NOLTA2024)
  
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[雑誌論文] One-Core Neuron Deep Learning for Time Series Prediction2024
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  Hao Peng, Pei Chen, Na Yang, Kazuyuki Aihara, Rui Liu, and Luonan Chen
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  National Science Review
  
  巻: 12 号: 2 ページ: nwae441-1-nwae441-14
- DOI
  10.1093/nsr/nwae441
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[雑誌論文] Identifying the crucial tipping point in the maturation process of cultured neurons using Raman spectroscopy and a dynamic network biomarker (DNB) analysis2024
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  Kosuke Hashimoto, Shota Yonezawa, Takayuki Haruki, Keiichi Koizumi, Yusuke Oshima, Isao Kitajima, Hidetoshi Sato, Shigeru Saito
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  Biochemical and Biophysical Research Communications
  
  巻: 743 号: - ページ: 151167-1-151167-6
- DOI
  10.1016/j.bbrc.2024.151167
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[雑誌論文] MTIOT: Identifying HPV Subtypes from Multiple Infection Data2024
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  Qi Zhao, Tianjun Zhou, Lin Li, Guofan Hong, Luonan Chen
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  Computational and Structural Biotechnology Journal
  
  巻: 27 号: - ページ: 149-159
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  10.1016/j.csbj.2024.12.005
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[雑誌論文] Two-Agent Noncooperative Dynamical Systems With Quadratic Vector-Valued Payoff Functions and Weak Pareto Improvement2024
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  Zehui Guo, Tomohisa Hayakawa
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  IEEE Control Systems Letters
  
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  10.1109/LCSYS.2024.3522596
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[雑誌論文] 反積分フィードバック制御系のDNB解析2024
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  石原峻, 中茎隆, 井村順一
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  自動制御連合講演会講演論文集
  
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  10.11511/jacc.67.0_467
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[雑誌論文] 健康・疾病状態のエネルギー地形解析と最適輸送理論を利用した介入2024
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  須賀悠仁, 井上正樹, 小野木康弘
- 雑誌名
  
  自動制御連合講演会講演論文集
  
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  10.11511/jacc.67.0_473
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[雑誌論文] Aging in a weighted ensemble of excitable and self-oscillatory neurons: The role of pairwise and higher-order interactions2024
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  Amit Sharma, Biswambhar Rakshit, Kazuyuki Aihara
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  Chaos
  
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  10.1063/5.0247769
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[雑誌論文] A modeling study to define guidelines for antigen screening in schools and workplaces to mitigate COVID-19 outbreaks2024
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  Yong Dam Jeong, Keisuke Ejima, Kwang Su Kim, Shoya Iwanami, William S Hart, Robin N Thompson, Il Hyo Jung, Shingo Iwami, Marco Ajelli, Kazuyuki Aihara
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  Communications Medicine
  
  巻: 5 号: - ページ: 2-1-2-13
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  10.1038/s43856-024-00716-3
- 査読あり / オープンアクセス / 国際共著
[雑誌論文] Blood DNA virome associates with autoimmune diseases and COVID-192024
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  Noah Sasa, Shohei Kojima, Rie Koide, Takanori Hasegawa, Ho Namkoong, Tomomitsu Hirota, Rei Watanabe, Yuumi Nakamura, Eri Oguro-Igashira, Kotaro Ogawa, Tomohiro Yata, Kyuto Sonehara, Kenichi Yamamoto, Toshihiro Kishikawa, Saori Sakaue, Ryuya Edahiro, Yuya Shirai, Yuichi Maeda, Takuro Nii, Shotaro Chubachi, Hiromu Tanaka, Haruka Yabukami, Akari Suzuki, Kimiko Nakajima, Noriko Arase, Takashi Okamoto, Rika Nishikawa, Shinichi Namba, Tatsuhiko Naito, Ippei Miyagawa, Hiroaki Tanaka, Masanobu Ueno, Yosuke Ishitsuka, Junichi Furuta, Kayo Kunimoto, Ikko Kajihara, Satoshi Fukushima, Hideaki Miyachi, Hiroyuki Matsue, Masahiro Kamata, Mami Momose, Toshinori Bito, Hiroshi Nagai, Tetsuya Ikeda, Tatsuya Horikawa, Atsuko Adachi, Tsukasa Matsubara, Kyoko Ikumi, Emi Nishida, Ikuma Nakagawa, Mayu Yagita-Sakamaki, Maiko Yoshimura, Shiro Ohshima, Makoto Kinoshita, Satoru Ito, Toru Arai, Masaki Hirose, Yoshinori Tanino, Takefumi Nikaido, Toshio Ichiwata, Shinya Ohkouchi, Taizou Hirano
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  Nature Genetics
  
  巻: 57 号: 1 ページ: 65-79
- DOI
  10.1038/s41588-024-02022-z
- 査読あり / オープンアクセス / 国際共著
[雑誌論文] Prediction of cccDNA dynamics in hepatitis B patients by a combination of serum surrogate markers2024
- 著者名
  Kwang Su Kim, Masashi Iwamoto, Kosaku Kitagawa, Hyeongki Park, Sanae Hayashi, Senko Tsukuda, Takeshi Matsui, Masanori Atsukawa, Kentaro Matsuura, Natthaya Chuaypen, Pisit Tangkijvanich, Lena Allweiss, Takara Nishiyama, Naotoshi Nakamura, Yasuhisa Fujita, Eiryo Kawakami, Shinji Nakaoka, Masamichi Muramatsu, Kazuyuki Aihara, Takaji Wakita, Alan S Perelson, Maura Dandri, Koichi Watashi, Shingo Iwami, Yasuhito Tanaka
- 雑誌名
  
  PLOS Computational Biology
  
  巻: 21 号: 1 ページ: e1012615-1-e1012615-20
- DOI
  10.1371/journal.pcbi.1012615
- 査読あり / オープンアクセス
[雑誌論文] Role of transforming growth factor-β1 in regulating adipocyte progenitors2024
- 著者名
  Nguyen Quynh Phuong, Muhammad Bilal, Allah Nawaz, Le Duc Anh, Memoona, Muhammad Rahil Aslam, Sana Khalid, Tomonobu Kado, Yoshiyuki Watanabe, Ayumi Nishimura, Yoshiko Igarashi, Keisuke Okabe, Kenichi Hirabayashi, Seiji Yamamoto, Takashi Nakagawa, Hisashi Mori, Isao Usui, Shiho Fujisaka, Ryuji Hayashi, Kazuyuki Tobe
- 雑誌名
  
  Scientific Reports
  
  巻: 15 号: 1 ページ: 941-1-941-12
- DOI
  10.1038/s41598-024-81917-7
- 査読あり / オープンアクセス
[雑誌論文] Incomplete human reference genomes can drive false sex biases and expose patient-identifying information in metagenomic data2024
- 著者名
  Caitlin Guccione, Lucas Patel, Yoshihiko Tomofuji, Daniel McDonald, Antonio Gonzalez, Gregory D Sepich-Poore, Kyuto Sonehara, Mohsen Zakeri, Yang Chen, Amanda Hazel Dilmore, Neil Damle, Sergio E Baranzini, George Hightower, Teruaki Nakatsuji, Richard L Gallo, Ben Langmead, Yukinori Okada, Kit Curtius, Rob Knight
- 雑誌名
  
  Nature Communications
  
  巻: 16 号: 1 ページ: 825-1-825-14
- DOI
  10.1038/s41467-025-56077-5
- 査読あり / オープンアクセス
[雑誌論文] Neural activity responsiveness by maturation of inhibition underlying critical period plasticity2024
- 著者名
  Ibuki Matsumoto, Sou Nobukawa, Takashi Kanamaru, Yusuke Sakemi, Nina Sviridova, Tomoki Kurikawa, Nobuhiko Wagatsuma, Kazuyuki Aihara
- 雑誌名
  
  Frontiers in Neural Circuits
  
  巻: 18 号: - ページ: 1519704-1-1519704-14
- DOI
  10.3389/fncir.2024.1519704
- 査読あり / オープンアクセス
[雑誌論文] Autocorrelation properties of temporal networks governed by dynamic node variables2024
- 著者名
  Harrison Hartle, Naoki Masuda
- 雑誌名
  
  Physical Review Research
  
  巻: 7 号: - ページ: 013083-1-013083-13
- DOI
  10.1103/PhysRevResearch.7.013083
- 査読あり / オープンアクセス / 国際共著
[雑誌論文] Diffusive topology preserving manifold distances for single-cell data analysis2024
- 著者名
  Jiangyong Wei, Bin Zhang, Qiu Wang, Tianshou Zhou, Tianhai Tian, Luonan Chen
- 雑誌名
  
  Proceedings of the National Academy of Sciences of the United States of America
  
  巻: 122 号: 4 ページ: e2404860121-1-e2404860121-10
- DOI
  10.1073/pnas.2404860121
- 査読あり / オープンアクセス
[雑誌論文] Intratumor heterogeneity of HPV integration in HPV-associated head and neck cancer2024
- 著者名
  Noah Sasa, Toshihiro Kishikawa, Masashi Mori, Rie Ito, Yumie Mizoro, Masami Suzuki, Hirotaka Eguchi, Hidenori Tanaka, Takahito Fukusumi, Motoyuki Suzuki, Yukinori Takenaka, Keisuke Nimura, Yukinori Okada, Hidenori Inohara
- 雑誌名
  
  Nature Communications
  
  巻: 16 号: 1 ページ: 1052-1-1052-22
- DOI
  10.1038/s41467-025-56150-z
- 査読あり / オープンアクセス
[雑誌論文] Brain Dynamics Simulation of Schizophrenia with Chaotic Neural Networks2024
- 著者名
  Guiyang Lv, Ping Zhu, Feiyan Chen, Kazuyuki Aihara, Guoguang He
- 雑誌名
  
  Neurocomputing
  
  巻: 626 号: - ページ: 129585-1-129585-11
- DOI
  10.1016/j.neucom.2025.129585
- 査読あり / オープンアクセス
[雑誌論文] An Attention‐Based Deep Neural Network Model to Detect Cis‐Regulatory Elements at the Single‐Cell Level From Multi‐Omics Data2024
- 著者名
  Ken Murakami, Keita Iida, Mariko Okada
- 雑誌名
  
  Genes to Cells
  
  巻: 30 号: 2 ページ: e70000-1-e70000-14
- DOI
  10.1111/gtc.70000
- 査読あり / オープンアクセス
[雑誌論文] Abnormal neuritic microstructures in the anterior limb of internal capsules in treatment-resistant depression-a cross-sectional NODDI study2024
- 著者名
  Koki Takahashi, Yoshihiro Noda, Nobuaki Hondo, Shuhei Shibukawa, Koji Kamagata, Masataka Wada, Shiori Honda, Saki Homma, Amaki Tsukazaki, Sakiko Tsugawa, Yui Tobari, Sotaro Moriyama, Keita Taniguchi, Shinsuke Koike, Clifford Cassidy, Masaru Mimura, Hiroyuki Uchida, Shinichiro Nakajima
- 雑誌名
  
  Journal of Psychiatric Research
  
  巻: 183 号: - ページ: 93-99
- DOI
  10.1016/j.jpsychires.2025.02.007
- 査読あり / オープンアクセス
[雑誌論文] Age-dependence of food allergy due to decreased supply of naive T cells2024
- 著者名
  Yuna Kotsubo, Akane Hara, Rena Hayashi, Yoh Iwasa
- 雑誌名
  
  Journal of Theoretical Biology
  
  巻: 602-603 号: - ページ: 112060-1-112060-9
- DOI
  10.1016/j.jtbi.2025.112060
- 査読あり / オープンアクセス
[雑誌論文] A pretrained transformer model for decoding individual glucose dynamics from continuous glucose monitoring data2024
- 著者名
  Yurun Lu, Dan Liu, Zhongming Liang, Rui Liu, Pei Chen, Yitong Liu, Jiachen Li, Zhanying Feng, Lei M Li, Bin Sheng, Weiping Jia, Luonan Chen, Huating Li, Yong Wang
- 雑誌名
  
  National Science Review
  
  巻: 12 号: 5 ページ: nwaf039-1-nwaf039-20
- DOI
  10.1093/nsr/nwaf039
- 査読あり / オープンアクセス
[雑誌論文] Identification of the Cellular Tipping Point in the Inflammation Model of LPS-Induced RAW264.7 Macrophages Through Raman Spectroscopy and the Dynamical Network Biomarker Theory2024
- 著者名
  Akinori Taketani, Shota Koshiyama, Takayuki Haruki, Shota Yonezawa, Jun Tahara, Moe Yamazaki, Yusuke Oshima, Akinori Wada, Tsutomu Sato, Keiichi Koizumi, Isao Kitajima, Shigeru Saito
- 雑誌名
  
  Molecules
  
  巻: 30 号: 4 ページ: 920-1-920-14
- DOI
  10.3390/molecules30040920
- 査読あり / オープンアクセス
[雑誌論文] Contribution of germline and somatic mutations to risk of neuromyelitis optica spectrum disorder2024
- 著者名
  Tomohiro Yata, Go Sato, Kotaro Ogawa, Tatsuhiko Naito, Kyuto Sonehara, Ryunosuke Saiki, Ryuya Edahiro, Shinichi Namba, Mitsuru Watanabe, Yuya Shirai, Kenichi Yamamoto, Ho NamKoong, Tomoko Nakanishi, Yuji Yamamoto, Akiko Hosokawa, Mamoru Yamamoto; Japan MS/NMOSD biobank; BioBank Japan Project; Japan COVID-19 Task Force; Eri Oguro-Igashira, Takuro Nii, Yuichi Maeda, Kimiko Nakajima, Rika Nishikawa, Hiroaki Tanaka, Shingo Nakayamada, Koichi Matsuda, Chikako Nishigori, Shigetoshi Sano, Makoto Kinoshita, Ryuji Koike, Akinori Kimura, Seiya Imoto, Satoru Miyano, Koichi Fukunaga, Masahito Mihara, Yuko Shimizu, Izumi Kawachi, Katsuichi Miyamoto, Yoshiya Tanaka, Atsushi Kumanogoh, Masaaki Niino, Yuji Nakatsuji, Seishi Ogawa, Takuya Matsushita, Jun-Ichi Kira, Hideki Mochizuki, Noriko Isobe, Tatsusada Okuno, Yukinori Okada
- 雑誌名
  
  Cell Genomics
  
  巻: 5 号: 3 ページ: 100776-1-100776-15
- DOI
  10.1016/j.xgen.2025.100776
- 査読あり / オープンアクセス
[雑誌論文] Proposal for a Novel Classification of Patients With Enlarged Ventricles and Cognitive Impairment Based on Data-Driven Analysis of Neuroimaging Results in Patients With Psychiatric Disorders2024
- 著者名
  Yuka Yasuda, Satsuki Ito, Junya Matsumoto, Naohiro Okada, Toshiaki Onitsuka, Masashi Ikeda, Itaru Kushima, Chika Sumiyoshi, Masaki Fukunaga, Kiyotaka Nemoto, Kenichiro Miura, Naoki Hashimoto, Kazutaka Ohi, Tsutomu Takahashi, Daiki Sasabayashi, Michihiko Koeda, Hidenaga Yamamori, Michiko Fujimoto, Harumasa Takano, Naomi Hasegawa, Hisashi Narita, Maeri Yamamoto, Khin Khin Tha, Masataka Kikuchi, Toshiharu Kamishikiryo, Eri Itai, Yoshiro Okubo, Amane Tateno, Motoaki Nakamura, Manabu Kubota, Hiroyuki Igarashi, Yoji Hirano, Go Okada, Jun Miyata, Shusuke Numata, Osamu Abe, Reiji Yoshimura, Shin Nakagawa, Hidenori Yamasue, Norio Ozaki, Kiyoto Kasai, Ryota Hashimoto
- 雑誌名
  
  Neuropsychopharmacology Reports
  
  巻: 45 号: 1 ページ: e70010-1-e70010-11
- DOI
  10.1002/npr2.70010
- 査読あり / オープンアクセス
[雑誌論文] Comprehensive evaluation of pipelines for classification of psychiatric disorders using multi-site resting-state fMRI datasets2024
- 著者名
  Yuji Takahara, Yuto Kashiwagi, Tomoki Tokuda, Junichiro Yoshimoto, Yuki Sakai, Ayumu Yamashita, Toshinori Yoshioka, Hidehiko Takahashi, Hiroto Mizuta, Kiyoto Kasai, Akira Kunimitsu, Naohiro Okada, Eri Itai, Hotaka Shinzato, Satoshi Yokoyama, Yoshikazu Masuda, Yuki Mitsuyama, Go Okada, Yasumasa Okamoto, Takashi Itahashi, Haruhisa Ohta, Ryu-Ichiro Hashimoto, Kenichiro Harada, Hirotaka Yamagata, Toshio Matsubara, Koji Matsuo, Saori C Tanaka, Hiroshi Imamizu, Koichi Ogawa, Sotaro Momosaki, Mitsuo Kawato, Okito Yamashita
- 雑誌名
  
  Neural Networks
  
  巻: 187 号: - ページ: 107335-1-107335-15
- DOI
  10.1016/j.neunet.2025.107335
- 査読あり / オープンアクセス
[雑誌論文] Germline variants and mosaic chromosomal alterations affect COVID-19 vaccine immunogenicity2024
- 著者名
  Kyuto Sonehara, Yoshifumi Uwamino, Ryunosuke Saiki, Masaru Takeshita, Shinichi Namba, Shunsuke Uno, Tomoko Nakanishi, Tomoyasu Nishimura, Tatsuhiko Naito, Go Sato, Masahiro Kanai, Aoxing Liu, Sho Uchida, Toshinobu Kurafuji, Akiko Tanabe, Tomoko Arai, Akemi Ohno, Ayako Shibata, Shiho Tanaka, Masatoshi Wakui, Shoko Kashimura, Chiharu Tomi, Akemi Hara, Shiori Yoshikawa, Keiko Gotanda, Kana Misawa, Hiromu Tanaka, Shuhei Azekawa, Qingbo S Wang, Ryuya Edahiro, Yuya Shirai, Kenichi Yamamoto, Genta Nagao, Takuo Suzuki, Masato Kiyoshi, Akiko Ishii-Watabe, Shinichi Higashiue, Shuzo Kobayashi, Hiroki Yamaguchi, Yasushi Okazaki, Naoyuki Matsumoto, Akihide Masumoto, Hidenobu Koga, Akinori Kanai; Yoshiya Oda, Yutaka Suzuki, Koichi Matsuda, Yuko Kitagawa, Ryuji Koike, Akinori Kimura, Atsushi Kumanogoh, Akihiko Yoshimura, Seiya Imoto, Satoru Miyano, Takanori Kanai, Koichi Fukunaga, Naoki Hasegawa, Mitsuru Murata, Hiromichi Matsushita, Seishi Ogawa, Yukinori Okada, Ho Namkoong
- 雑誌名
  
  Cell Genomics
  
  巻: 5 号: 3 ページ: 100783-1-100783-17
- DOI
  10.1016/j.xgen.2025.100783
- 査読あり / オープンアクセス
[雑誌論文] Horseshoes for a Class of Nonuniformly Expanding Random Circle Maps2024
- 著者名
  Jeroen S. W. Lamb, Giuseppe Tenaglia, Dmitry Turaev
- 雑誌名
  
  Annales Henri Poincar
  
  巻: - 号: - ページ: ---
- DOI
  10.1007/s00023-025-01555-1
- 査読あり / オープンアクセス
[雑誌論文] NetNiche: Microbe-Metabolite Network Reconstruction and Microbial Niche Analysis2024
- 著者名
  Lu Wang, Lequn Wang, Luonan Chen
- 雑誌名
  
  Phenomics
  
  巻: 5 号: 2 ページ: 208-211
- DOI
  10.1007/s43657-024-00168-8
- 査読あり / オープンアクセス
[雑誌論文] Designing chaotic attractors: A semisupervised approach2024
- 著者名
  Tempei Kabayama, Yasuo Kuniyoshi, Kazuyuki Aihara, Kohei Nakajima
- 雑誌名
  
  Physical Review E
  
  巻: 111 号: 3 ページ: 034207-1-034207-10
- DOI
  10.1103/PhysRevE.111.034207
- 査読あり / オープンアクセス
[雑誌論文] Integration of dynamical network biomarkers, control theory and Drosophila model identifies Vasa/DDX4 as the potential therapeutic targets for metabolic syndrome2024
- 著者名
  Kazutaka Akagi, Ying-Jie Jin, Keiichi Koizumi, Makito Oku, Kaisei Ito, Xun Shen, Jun-ichi Imura, Kazuyuki Aihara, Shigeru Saito
- 雑誌名
  
  Cells
  
  巻: 14 号: 6 ページ: 415-1-415-15
- DOI
  10.3390/cells14060415
- 査読あり / オープンアクセス
[雑誌論文] Revealing Cell-Cell Communication Pathways with Their Spatially Coupled Gene Programs2024
- 著者名
  Hiroyuki Kitajima, Kentaro Takeda, Makoto Ishizawa, Kazuyuki Aihara, Tetsuo Minamino
- 雑誌名
  
  Chaos
  
  巻: 35 号: 3 ページ: 33137-1-33137-11
- DOI
  10.1063/5.0212068
- 査読あり / オープンアクセス
[雑誌論文] Potential multiple disease progression pathways in female patients with Alzheimer’s disease inferred from transcriptome and epigenome data of the dorsolateral prefrontal cortex2024
- 著者名
  Kousei Honda, Akinori Awazu
- 雑誌名
  
  PLoS One
  
  巻: 20 号: 3 ページ: e0313733-1-e0313733-34
- DOI
  10.1371/journal.pone.0313733
- 査読あり / オープンアクセス
[雑誌論文] In vitro and in vivo analysis in NIR-PDD combining multiphoton excitation and 5-ALA2024
- 著者名
  Shoki Yashiki, Katsuhiro Ogawa, Hidefumi Shiroshita, Masafumi Inomata, Takashi Katagiri, Yusuke Oshima
- 雑誌名
  
  Proceedings of SPIE
  
  巻: 13299 号: - ページ: 1329903--
- DOI
  10.1117/12.3045327
- 査読あり / オープンアクセス
[雑誌論文] Characterization of bone marrow cells for prognosis prediction of multiple myeloma using Raman spectroscopy with optimal discriminant model2024
- 著者名
  Yusuke Oshima, Akinori Taketani, Shota Yonezawa, Takayuki Haruki, Akinori Wada, Tsutomu Sato, Keiichi Koizumi
- 雑誌名
  
  Proceedings of SPIE
  
  巻: 13311 号: - ページ: 1331102--
- DOI
  10.1117/12.3046725
- 査読あり / オープンアクセス
[雑誌論文] Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD+ synthesis via enterohepatic circulation2024
- 著者名
  Keisuke Yaku, Sailesh Palikhe, Tooba Iqbal, Faisal Hayat, Yoshiyuki Watanabe, Shiho Fujisaka, Hironori Izumi, Tomoyuki Yoshida, Mariam Karim, Hitoshi Uchida, Allah Nawaz, Kazuyuki Tobe, Hisashi Mori, Marie E Migaud, Takashi Nakagawa
- 雑誌名
  
  Science Advances
  
  巻: 11 号: 12 ページ: eadr1538-1-eadr1538-16
- DOI
  10.1126/sciadv.adr1538
- 査読あり / オープンアクセス
[雑誌論文] Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism2024
- 著者名
  Hiroshi Tsuneki, Takahiro Maeda, Mayumi Takatsuki, Takahiro Sekine, Satsuki Masui, Kengo Onishi, Ryuta Takeda, Masanori Sugiyama, Takeshi Sakurai, Masashi Yanagisawa, Tsutomu Wada, Toshiyasu Sasaoka
- 雑誌名
  
  PLoS ONE
  
  巻: 20 号: 3 ページ: e0320157-1-e0320157-24
- DOI
  10.1371/journal.pone.0320157
- 査読あり / オープンアクセス

複雑臓器制御系の数理的包括理解と超早期精密医療への挑戦

研究代表者

合原 一幸 東京大学, 特別教授

報告書

主な研究成果

[雑誌論文] Positive and Negative Feedback Regulation of the TGF-β1 Explains Two Equilibrium States in Skin Aging2024

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[雑誌論文] Impact of time-history terms on reservoir dynamics and prediction accuracy in echo state networks2024

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[雑誌論文] New Directions for Advanced Targeting Strategies of EGFR Signaling in Cancer2024

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[雑誌論文] Modeling and Predicting Individual Variation in COVID-19 Vaccine-Elicited Antibody Response in the General Population2024

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[雑誌論文] Revealing Cell-Cell Communication Pathways with Their Spatially Coupled Gene Programs2024

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[雑誌論文] Incorporation of likely future actions of agents into pseudo-gradient dynamics of noncooperative games2024

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[雑誌論文] Effects of pseudobulk and Gaussian noise on the application of the dynamical network biomarker theory to single-cell RNA-seq data2024

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[雑誌論文] Identifying Key Regulatory Genes in Drug Resistance Acquisition: Modeling Pseudotime Trajectories of Breast Cancer Single-Cell Transcriptome2024

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[雑誌論文] Brugada Syndrome in Japan and Europe: a Genome-Wide Association Study Reveals Shared Genetic Architecture and New Risk Loci2024

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[雑誌論文] Podocyte Pathogenic Bone Morphogenetic Protein-2 Pathway and Immune Cell Behaviors in Primary Membranous Nephropathy2024

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[雑誌論文] Multi-Modal Domain Adaptation for Revealing Spatial Functional Landscape from Spatially Resolved Transcriptomics2024

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[雑誌論文] Reliability of energy landscape analysis of resting-state functional MRI data2024

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[雑誌論文] Evolutionary game dynamics with environmental feedback in a network with two communities2024

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[雑誌論文] Physical and Psychosocial Factors Associated with Fatigue in Individuals with 22q11.2 Deletion Syndrome2024

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[雑誌論文] Body Mass Index Stratification Optimizes Polygenic Prediction of Type 2 Diabetes in Cross-Biobank Analyses2024

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[雑誌論文] Dissecting Tumor Microenvironment from Spatially Resolved Transcriptomics Data by Heterogeneous Graph Learning2024

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[雑誌論文] An Energy Landscape Approach Reveals the Potential Key Bacteria Contributing to the Development of Inflammatory Bowel Disease2024

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[雑誌論文] Abnormal Resting-State Hyperconnectivity in Schizophrenia: A Whole-Head Near-Infrared Spectroscopy Study2024

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[雑誌論文] Psychotic Experiences and Dissociation in Adolescents: Within-Person Analysis in the Tokyo Teen Cohort2024

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合原一幸東京大学, 特別教授