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抗腫瘍免疫応答に重要な真のネオ抗原の同定と発がんとの関係解明

研究課題

戦略的な研究開発の推進 創発的研究支援事業

体系的番号 JPMJFR2049
DOI https://doi.org/10.52926/JPMJFR2049

研究代表者

冨樫 庸介  岡山大学, 大学院医歯薬学総合研究科, 教授

研究期間 (年度) 2021 – 2027 (予定)
概要がん免疫療法の効果は未だ満足のいくものではないです。がん免疫では遺伝子変異由来の「ネオ抗原」が注目されていますが、従来の「ネオ抗原」だけでは説明できない現象も多く、本研究では今まで注目されていない遺伝子や免疫細胞に踏み込み、「真のネオ抗原」を同定して治療応用を目指します。またがんになる手前の病変でも「真のネオ抗原」含めどのような免疫状態になっているか解明し、がんの予防方法などに応用します。
研究領域水島パネル

報告書

(5件)
  • 2024 年次報告書 ( PDF )
  • 2023 中間評価書 ( PDF )   年次報告書 ( PDF )
  • 2022 年次報告書 ( PDF )
  • 2021 年次報告書 ( PDF )
  • 主な研究成果

    (12件)

すべて 2024

すべて 雑誌論文 (12件) (査読あり 12件、 オープンアクセス 7件)

  • [雑誌論文] Soluble immune checkpoint factors reflect exhaustion of antitumor immunity and response to PD-1 blockade2024

    • 著者名
      Hidetoshi Hayashi, Kenji Chamoto, Ryusuke Hatae, Takashi Kurosaki, Yosuke Togashi, Kazuya Fukuoka, Megumi Goto, Yasutaka Chiba, Shuta Tomida, Takayo Ota, Koji Haratani, Takayuki Takahama, Junko Tanizaki, Takeshi Yoshida, Tsutomu Iwasa, Kaoru Tanaka, Masayuki Takeda, Tomoko Hirano, Hironori Yoshida, Hiroaki Ozasa, Yuichi Sakamori, Kazuko Sakai, Keiko Higuchi, Hitoshi Uga, Chihiro Suminaka, Toyohiro Hirai, Kazuto Nishio, Kazuhiko Nakagawa, Tasuku Honjo
    • 雑誌名

      Journal of Clinical Investigation

      巻: 134 号: 7

    • 査読あり / オープンアクセス
  • [雑誌論文] CD106 in tumor-specific exhausted CD8+ T cells mediates immunosuppression by inhibiting TCR signaling.2024

    • 著者名
      Yuto Naoi, Takao Morinaga, Joji Nagasaki, Ryo Ariyasu, Youki Ueda, Kazuo Yamashita, Wenhao Zhou, Shusuke Kawashima, Katsushige Kawase, Akiko Honobe-Tabuchi, Takehiro Ohnuma, Tatsuyoshi Kawamura, Yoshiyasu Umeda, Yu Kawahara, Yasuhiro Nakamura, Yukiko Kiniwa, Osamu Yamasaki, Satoshi Fukushima, Masahito Kawazu, Yutaka Suzuki, Hiroyoshi Nishikawa, Toyoyuki Hanazawa, Mizuo Ando, Takashi Inozume, Yosuke Togashi
    • 雑誌名

      Cancer research

    • 査読あり
  • [雑誌論文] Targeting PAK1 is effective against cutaneous squamous cell carcinoma in a syngenic mouse model.2024

    • 著者名
      Kazuhiro Okumura, Takao Morinaga, Megumi Saito, Yurika Tokunaga, Keisuke Otoyama, Sora Tanaka, Eriko Isogai, Masahito Kawazu, Yosuke Togashi, Yoshinori Hasegawa, Yuichi Wakabayashi
    • 雑誌名

      Cancer science

      巻: 115 号: 8 ページ: 2839-2845

    • 査読あり / オープンアクセス
  • [雑誌論文] Overcoming immunotherapy resistance and inducing abscopal effects with boron neutron immunotherapy (B-NIT).2024

    • 著者名
      Takuya Fujimoto, Osamu Yamasaki, Noriyuki Kanehira, Hirokazu Matsushita, Yoshinori Sakurai, Naoya Kenmotsu, Ryo Mizuta, Natsuko Kondo, Takushi Takata, Mizuki Kitamatsu, Kazuyo Igawa, Atsushi Fujimura, Yoshihiro Otani, Makoto Shirakawa, Kunitoshi Shigeyasu, Fuminori Teraishi, Yosuke Togashi, Minoru Suzuki, Toshiyoshi Fujiwara, Hiroyuki Michiue
    • 雑誌名

      Cancer science

      巻: 115 号: 10 ページ: 3231-3247

    • 査読あり / オープンアクセス
  • [雑誌論文] Fatty acid metabolism constrains Th9 cell differentiation and antitumor immunity via the modulation of retinoic acid receptor signaling.2024

    • 著者名
      Takahiro Nakajima, Toshio Kanno, Yuki Ueda, Keisuke Miyako, Takeru Endo, Souta Yoshida, Satoru Yokoyama, Hikari K Asou, Kazuko Yamada, Kazutaka Ikeda, Yosuke Togashi, Yusuke Endo
    • 雑誌名

      Cellular & molecular immunology

      巻: 21 号: 11 ページ: 1350-1350

    • 査読あり / オープンアクセス
  • [雑誌論文] Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity.2024

    • 著者名
      Fumiaki Mukohara, Kazuma Iwata, Takamasa Ishino, Takashi Inozume, Joji Nagasaki, Youki Ueda, Ken Suzawa, Toshihide Ueno, Hideki Ikeda, Katsushige Kawase, Yuka Saeki, Shusuke Kawashima, Kazuo Yamashita, Yu Kawahara, Yasuhiro Nakamura, Akiko Honobe-Tabuchi, Hiroko Watanabe, Hiromichi Dansako, Tatsuyoshi Kawamura, Yutaka Suzuki, Hiroaki Honda, Hiroyuki Mano, Shinichi Toyooka, Masahito Kawazu, Yosuke Togashi
    • 雑誌名

      Proceedings of the National Academy of Sciences of the United States of America

      巻: 121 号: 35

    • 査読あり
  • [雑誌論文] The HSP90 Inhibitor Pimitespib Targets Regulatory T Cells in the Tumor Microenvironment.2024

    • 著者名
      Ayaka Tsuge, Sho Watanabe, Akihito Kawazoe, Yosuke Togashi, Kota Itahashi, Mari Masuda, Atsuo Sai, Shogo Takei, Hiromi Muraoka, Shuichi Ohkubo, Daisuke Sugiyama, Yue Yan, Shota Fukuoka, Toshihiko Doi, Kohei Shitara, Shohei Koyama, Hiroyoshi Nishikawa
    • 雑誌名

      Cancer immunology research

      巻: 13 号: 2 ページ: 273-285

    • 査読あり
  • [雑誌論文] The tumor immune microenvironment and therapeutic efficacy of trastuzumab deruxtecan in gastric cancer.2024

    • 著者名
      Shigehiro Koganemaru, Shohei Koyama, Fumitaka Suto, Makito Koga, Koichiro Inaki, Yusuke Kuwahara, Takeo Arita, Tsuyoshi Hirata, Hiroki Goto, Naoya Wada, Maki Kobayashi, Tomoko Shibutani, Tatsuya Okabayashi, Kenji Nakamaru, Akihito Kawazoe, Yosuke Togashi, Hiroyoshi Nishikawa, Kohei Shitara
    • 雑誌名

      Cancer research communications

    • 査読あり / オープンアクセス
  • [雑誌論文] Myeloid Cells Induce Infiltration and Activation of B Cells and CD4+ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy.2024

    • 著者名
      Toshifumi Ninomiya, Naoya Kemmotsu, Fumiaki Mukohara, Masaki Magari, Ai Miyamoto, Youki Ueda, Takamasa Ishino, Joji Nagasaki, Tomohiro Fujiwara, Hidetaka Yamamoto, Hidetoshi Hayashi, Kota Tachibana, Joji Ishida, Yoshihiro Otani, Shota Tanaka, Shinichi Toyooka, Isamu Okamoto, Yosuke Togashi
    • 雑誌名

      Cancer research

    • 査読あり
  • [雑誌論文] Immune evasion through mitochondrial transfer in the tumour microenvironment.2024

    • 著者名
      Hideki Ikeda, Katsushige Kawase, Tatsuya Nishi, Tomofumi Watanabe, Keizo Takenaga, Takashi Inozume, Takamasa Ishino, Sho Aki, Jason Lin, Shusuke Kawashima, Joji Nagasaki, Youki Ueda, Shinichiro Suzuki, Hideki Makinoshima, Makiko Itami, Yuki Nakamura, Yasutoshi Tatsumi, Yusuke Suenaga, Takao Morinaga, Akiko Honobe-Tabuchi, Takehiro Ohnuma, Tatsuyoshi Kawamura, Yoshiyasu Umeda, Yasuhiro Nakamura, Yukiko Kiniwa, Eiki Ichihara, Hidetoshi Hayashi, Jun-Ichiro Ikeda, Toyoyuki Hanazawa, Shinichi Toyooka, Hiroyuki Mano, Takuji Suzuki, Tsuyoshi Osawa, Masahito Kawazu, Yosuke Togashi
    • 雑誌名

      Nature

      巻: 638 号: 8049 ページ: 225-236

    • 査読あり / オープンアクセス
  • [雑誌論文] High Antigenicity for Treg Cells Confers Resistance to PD-1 Blockade Therapy via High PD-1 Expression in Treg Cells.2024

    • 著者名
      Hiroaki Matsuura, Takamasa Ishino, Toshifumi Ninomiya, Kiichiro Ninomiya, Kota Tachibana, Akiko Honobe-Tabuchi, Yoshinori Muto, Takashi Inozume, Youki Ueda, Kadoaki Ohashi, Yoshinobu Maeda, Joji Nagasaki, Yosuke Togashi
    • 雑誌名

      Cancer science

    • 査読あり / オープンアクセス
  • [雑誌論文] Efficacy of amivantamab, a bi-specific antibody targeting EGFR and MET, in ALK-rearranged non-small-cell lung cancer cell lines.2024

    • 著者名
      Tatsuya Nishi, Ayako Morita, Naofumi Hara, Go Makimoto, Kiichiro Ninomiya, Masanori Fujii, Kammei Rai, Kadoaki Ohashi, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Eiki Ichihara
    • 雑誌名

      Lung cancer (Amsterdam, Netherlands)

      巻: 201 ページ: 108415-108415

    • 査読あり

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JSTプロジェクトデータベース掲載開始日: 2021-07-12   JSTプロジェクトデータベース最終更新日: 2026-09-08  

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