電子伝達体をプローブとする多重超偏極イメージング法の創成

研究課題

体系的番号	JPMJFR2168
DOI	https://doi.org/10.52926/JPMJFR2168
研究代表者	兵藤文紀岐阜大学, 高等研究院, 准教授
研究期間 (年度)	2022 – 2028 (予定)
概要	本研究では、生体内に存在する分子そのものをプローブとした分子診断技術の創成に挑戦します。電子の授受を媒介する電子伝達体は生合成や代謝を担い、その挙動は生理機能のみならず多くの疾患に関与します。電子伝達体を超高感度MRI（DNP）プローブとすることで、生命活動における生合成や代謝反応・神経伝達を直接かつリアルタイムで可視化する技術を開発し、超早期診断や未病の検知に資する新技術を創出します。
研究領域	水島パネル

報告書

(4件)

主な研究成果
(16件)

すべて 2024

すべて雑誌論文 (16件) (国際共著 4件、査読あり 16件、オープンアクセス 12件)

[雑誌論文] Effect of X-ray tube on image quality and pancreatic ductal adenocarcinoma conspicuity in pancreatic protocol dual-energy CT.2024
- 著者名
  Y Noda, Y Takai, T Suto, N Yamada, T Mori, N Kawai, T Kaga, F Hyodo, H Kato, M Matsuo
- 雑誌名
  
  Clinical radiology
  
  巻: 79 号: 4
- 査読あり / オープンアクセス
[雑誌論文] CT and MRI findings of small cell neuroendocrine carcinoma of the urinary bladder: comparison with urothelial carcinoma.2024
- 著者名
  Masaya Kawaguchi, Hiroki Kato, Takuya Koie, Yoshifumi Noda, Fuminori Hyodo, Tatsuhiko Miyazaki, Masayuki Matsuo
- 雑誌名
  
  Abdominal radiology (New York)
- 査読あり / オープンアクセス
[雑誌論文] Prognostic value of radiological T category using conventional MRI in patients with oral tongue cancer: comparison with pathological T category.2024
- 著者名
  Masaya Kawaguchi, Hiroki Kato, Tomohiro Kanayama, Hiroyuki Tomita, Akira Hara, Hirofumi Shibata, Takenori Ogawa, Daijiro Hatakeyama, Yoichi Yamada, Tomohiro Ando, Yoshifumi Noda, Fuminori Hyodo, Masayuki Matsuo
- 雑誌名
  
  Neuroradiology
- 査読あり / オープンアクセス
[雑誌論文] FDG uptake in the cervical muscles after neck dissection: imaging features and postoperative natural course on 18F?FDG?PET/CT.2024
- 著者名
  Yukako Iritani, Hiroki Kato, Yo Kaneko, Takuma Ishihara, Tomohiro Ando, Masaya Kawaguchi, Hirofumi Shibata, Takenori Ogawa, Yoshifumi Noda, Fuminori Hyodo, Masayuki Matsuo
- 雑誌名
  
  Japanese journal of radiology
- 査読あり / オープンアクセス
[雑誌論文] Assessment of Arterial Involvement in Pancreatic Cancer: Utility of Reconstructed CT Images Perpendicular to Artery.2024
- 著者名
  Yoshifumi Noda, Kazuhiro Kobayashi, Masaya Kawaguchi, Tomohiro Ando, Yukiko Takai, Taketo Suto, Yukako Iritani, Takuma Ishihara, Masahiro Fukada, Katsutoshi Murase, Nobuyuki Kawai, Tetsuro Kaga, Toshiharu Miyoshi, Fuminori Hyodo, Hiroki Kato, Tatsuhiko Miyazaki, Nobuhisa Matsuhashi, Kazuhiro Yoshida, Masayuki Matsuo
- 雑誌名
  
  Cancers
  
  巻: 16 号: 12
- 査読あり / オープンアクセス
[雑誌論文] Diffusion-weighted Echo Planar Imaging with Compressed SENSE (EPICS-DWI) for Pancreas Assessment: A Multicenter Study.2024
- 著者名
  Tetsuro Kaga, Yoshifumi Noda, Masashi Asano, Nobuyuki Kawai, Kimihiro Kajita, Yukiko Takai, Fumitaka Ejima, Fuminori Hyodo, Hiroki Kato, Yoshihiko Fukukura, Masayuki Matsuo
- 雑誌名
  
  Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
- 査読あり / オープンアクセス
[雑誌論文] Thyroid hemiatrophy associated with papillary thyroid carcinoma.2024
- 著者名
  Takuya Seko, Hiroki Kato, Tomohiro Ando, Kazuhiro Kobayashi, Hirofumi Shibata, Takenori Ogawa, Masaya Kawaguchi, Yoshifumi Noda, Fuminori Hyodo, Masayuki Matsuo
- 雑誌名
  
  Neuroradiology
- 査読あり / オープンアクセス
[雑誌論文] Correction: A comparative analysis of MRI findings in endometrial cancer: differentiation between endometrioid adenocarcinoma, serous carcinoma, and clear cell carcinoma.2024
- 著者名
  Takayuki Mori, Hiroki Kato, Masaya Kawaguchi, Yuichiro Hatano, Takuma Ishihara, Yoshifumi Noda, Fuminori Hyodo, Masayuki Matsuo, Tatsuro Furui, Ken-Ichirou Morishige
- 雑誌名
  
  European radiology
- 査読あり / オープンアクセス
[雑誌論文] MRI features of histological subtypes of thyroid cancer in comparison with CT findings: differentiation between anaplastic, poorly differentiated, and papillary thyroid carcinoma2024
- 著者名
  Takahide Maeda, Hiroki Kato, Tomohiro Ando, Masaya Kawaguchi, Hirofumi Shibata, Takenori Ogawa, Yoshifumi Noda, Fuminori Hyodo, Masayuki Matsuo
- 雑誌名
  
  Japanese Journal of Radiology
- 査読あり / オープンアクセス
[雑誌論文] In vivo redox imaging of plasma-induced skin-inflammation in mice2024
- 著者名
  Yassien Badr, Abdelazim Elsayed Elhelaly, Fuminori Hyodo, Koki Ichihashi, Hiroyuki Tomita, Yoshifumi Noda, Hiroki Kato, Masayuki Matsuo
- 雑誌名
  
  NPJ Imaging
- 査読あり / オープンアクセス / 国際共著
[雑誌論文] Optimized versus conventional trigger threshold for pancreatic phase image acquisition using dual-energy CT at 40-keV: a randomized controlled trial.2024
- 著者名
  Yoshifumi Noda, Hiromi Koyasu, Avinash Kambadakone, Nobuyuki Kawai, Takuya Naruse, Akio Ito, Tetsuro Kaga, Fuminori Hyodo, Hiroki Kato, Masayuki Matsuo
- 雑誌名
  
  Abdominal radiology (New York)
- 査読あり
[雑誌論文] Directly monitoring the dynamic in vivo metabolisms of hyperpolarized 13C-oligopeptides.2024
- 著者名
  Yohei Kondo, Yutaro Saito, Tomohiro Seki, Yoichi Takakusagi, Norikazu Koyasu, Keita Saito, Jumpei Morimoto, Hiroshi Nonaka, Koichiro Miyanishi, Wataru Mizukami, Makoto Negoro, Abdelazim E Elhelaly, Fuminori Hyodo, Masayuki Matsuo, Natarajan Raju, Rolf E Swenson, Murali C Krishna, Kazutoshi Yamamoto, Shinsuke Sando
- 雑誌名
  
  Science advances
  
  巻: 10 号: 42
- 査読あり / 国際共著
[雑誌論文] Quantitative spatial visualization of X-ray irradiation via redox reaction by dynamic nuclear polarization magnetic resonance imaging2024
- 著者名
  Norikazu Koyasu, Fuminori Hyodo*, Ryota Iwasaki, Abdelazim Elsayed Elhelaly, Takashi Mori, Yoshifumi Noda, Hiroki Kato, Murali C. Krishna, Shun Kishimoto, Masayuki Matsuo
- 雑誌名
  
  Free radical biology and medicine in press
  
  巻: 225 ページ: 388-397
- 査読あり / オープンアクセス / 国際共著
[雑誌論文] Dual inhibition of oxidative phosphorylation and glycolysis exerts a synergistic antitumor effect on colorectal and gastric cancer by creating energy depletion and preventing metabolic switch2024
- 著者名
  Yuki Aisu, Nobu Oshima, Fuminori Hyodo, Abdelazim Elsayed Elhelaly, Akihiko Masuo, Tomoaki Okada, Shigeo Hisamori, Shigeru Tsunoda, Koya Hida, Tomonori Morimoto, Hiroyuki Miyoshi, Makoto M. Taketo, Masayuki Matsuo, Leonard M. Neckers, Yoshiharu Sakai, Kazutaka Obama
- 雑誌名
  
  PLOS ONE
  
  巻: 19 号: 12
- 査読あり / オープンアクセス / 国際共著
[雑誌論文] Prediction of grading of ovarian endometrioid carcinoma using conventional MRI features.2024
- 著者名
  Masaya Kawaguchi, Hiroki Kato, Tatsuro Furui, Masanori Isobe, Yoshifumi Noda, Fuminori Hyodo, Tatsuhiko Miyazaki, Masayuki Matsuo
- 雑誌名
  
  Japanese journal of radiology
- 査読あり
[雑誌論文] Imaging Findings of Human Papillomavirus-Positive and Human Papillomavirus-Negative Oropharyngeal Squamous Cell Carcinoma Associated with Recurrence2024
- 著者名
  Taketo Suto, Masaya Kawaguchi, Hiroki Kato, Hirofumi Shibata, Takenori Ogawa, Tomohiro Ando, Yoshifumi Noda, Fuminori Hyodo, Masayuki Matsuo
- 雑誌名
  
  JOURNAL OF CLINICAL MEDICINE
  
  巻: 14 号: 3 ページ: 1027-1027
- 査読あり

電子伝達体をプローブとする多重超偏極イメージング法の創成

研究代表者

兵藤 文紀 岐阜大学, 高等研究院, 准教授

報告書

主な研究成果

[雑誌論文] Effect of X-ray tube on image quality and pancreatic ductal adenocarcinoma conspicuity in pancreatic protocol dual-energy CT.2024

著者名

雑誌名

[雑誌論文] CT and MRI findings of small cell neuroendocrine carcinoma of the urinary bladder: comparison with urothelial carcinoma.2024

著者名

雑誌名

[雑誌論文] Prognostic value of radiological T category using conventional MRI in patients with oral tongue cancer: comparison with pathological T category.2024

著者名

雑誌名

[雑誌論文] FDG uptake in the cervical muscles after neck dissection: imaging features and postoperative natural course on 18F?FDG?PET/CT.2024

著者名

雑誌名

[雑誌論文] Assessment of Arterial Involvement in Pancreatic Cancer: Utility of Reconstructed CT Images Perpendicular to Artery.2024

著者名

雑誌名

[雑誌論文] Diffusion-weighted Echo Planar Imaging with Compressed SENSE (EPICS-DWI) for Pancreas Assessment: A Multicenter Study.2024

著者名

雑誌名

[雑誌論文] Thyroid hemiatrophy associated with papillary thyroid carcinoma.2024

著者名

雑誌名

[雑誌論文] Correction: A comparative analysis of MRI findings in endometrial cancer: differentiation between endometrioid adenocarcinoma, serous carcinoma, and clear cell carcinoma.2024

著者名

雑誌名

[雑誌論文] MRI features of histological subtypes of thyroid cancer in comparison with CT findings: differentiation between anaplastic, poorly differentiated, and papillary thyroid carcinoma2024

著者名

雑誌名

[雑誌論文] In vivo redox imaging of plasma-induced skin-inflammation in mice2024

著者名

雑誌名

[雑誌論文] Optimized versus conventional trigger threshold for pancreatic phase image acquisition using dual-energy CT at 40-keV: a randomized controlled trial.2024

著者名

雑誌名

[雑誌論文] Directly monitoring the dynamic in vivo metabolisms of hyperpolarized 13C-oligopeptides.2024

著者名

雑誌名

[雑誌論文] Quantitative spatial visualization of X-ray irradiation via redox reaction by dynamic nuclear polarization magnetic resonance imaging2024

著者名

雑誌名

[雑誌論文] Dual inhibition of oxidative phosphorylation and glycolysis exerts a synergistic antitumor effect on colorectal and gastric cancer by creating energy depletion and preventing metabolic switch2024

著者名

雑誌名

[雑誌論文] Prediction of grading of ovarian endometrioid carcinoma using conventional MRI features.2024

著者名

雑誌名

[雑誌論文] Imaging Findings of Human Papillomavirus-Positive and Human Papillomavirus-Negative Oropharyngeal Squamous Cell Carcinoma Associated with Recurrence2024

著者名

雑誌名

兵藤文紀岐阜大学, 高等研究院, 准教授