リアルワールドテキスト処理の深化によるデータ駆動型探薬

研究課題

体系的番号	JPMJCR22N1
DOI	https://doi.org/10.52926/JPMJCR22N1
研究代表者	荒牧英治奈良先端科学技術大学院大学, 先端科学技術研究科, 教授
研究期間 (年度)	2022 – 2027
概要	DXの時代，電子カルテなどの病院文書，薬局の記録など，これまでにない膨大な量の医療データがテキストの形で蓄積されつつあります．しかし，その多くは，まだ，解析されていません．我々は，この膨大なテキストデータを自然言語処理するプラットフォームを開発します．そして，がん治療に伴う有害事象を抑制する最適な医薬品やその組み合わせを，自動的かつ大量に発見することを目指します．
研究領域	データ駆動・AI駆動を中心としたデジタルトランスフォーメーションによる生命科学研究の革新

主な研究成果
(17件)

すべて 2024

すべて雑誌論文 (17件) (査読あり 17件、オープンアクセス 17件)

[雑誌論文] Evaluation of deep learning models for adverse event signal detection using patients’ concerns in pharmaceutical care records.2024
- 著者名
  Nishioka S, Watabe S, Yanagisawa Y, Sayama K, Kizaki H, Imai S, Someya M, Taniguchi R, Yada S, Aramaki E, Hori S
- 雑誌名
  
  J Med Internet Res
  
  巻: 26
- 査読あり / オープンアクセス
[雑誌論文] A cross-sectional survey of hepatitis B virus screening in patients who received immunosuppressive therapy for rheumatoid arthritis in Japan.2024
- 著者名
  Yanagisawa Y, Imai S, Kizaki H, Hori S
- 雑誌名
  
  J Pharm Health Care Sci.
  
  巻: 10 号: 1 ページ: 18-18
- 査読あり / オープンアクセス
[雑誌論文] Using the natural language processing system MedNER-J to analyze pharmaceutical care records2024
- 著者名
  Yukiko Ohno, Riri Kato, Haruki Ishikawa, Tomohiro Nishiyama, Minae Isawa, Mayumi Mochizuki, Eiji Aramaki, Tohru Aomori
- 雑誌名
  
  JMIR Formative Research
- 査読あり / オープンアクセス
[雑誌論文] Differing Content and Language Based on Poster-Patient Relationships on the Chinese Social Media Platform Weibo: Text Classification, Sentiment Analysis, and Topic Modeling of Posts on Breast Cancer2024
- 著者名
  Zhouqing Zhang, Kongmeng Liew, Roeline Kuijer, Wan Jou She, Shuntaro Yada, Shoko Wakamiya, Eiji Aramaki
- 雑誌名
  
  JMIR Cancer
- 査読あり / オープンアクセス
[雑誌論文] Concomitant use of lansoprazole and ceftriaxone is associated with an increased risk of ventricular arrhythmias and cardiac arrest in a large Japanese hospital database.2024
- 著者名
  Satoru Mitsuboshi, Shungo Imai, Hayato Kizaki, Satoko Hori
- 雑誌名
  
  The Journal of infection
  
  巻: 89 号: 2 ページ: 106202-106202
- 査読あり / オープンアクセス
[雑誌論文] Is Boundary Annotation Necessary? Evaluating Boundary-Free Approaches to Improve Clinical Named Entity Annotation Efficiency: Case Study2024
- 著者名
  Gabriel Herman Bernardim Andrad, Shuntaro Yada, Eiji Aramaki
- 雑誌名
  
  JMIR Medical Informatics
- 査読あり / オープンアクセス
[雑誌論文] External Validation and Update of the Risk Prediction Model for Denosumab-Induced Hypocalcemia Developed From a Hospital-Based Administrative Database.2024
- 著者名
  Keisuke Ikegami, Shungo Imai, Osamu Yasumuro, Masami Tsuchiya, Naomi Henmi, Mariko Suzuki, Katsuhisa Hayashi, Chisato Miura, Haruna Abe, Hayato Kizaki, Ryohkan Funakoshi, Yasunori Sato, Satoko Hori
- 雑誌名
  
  JCO clinical cancer informatics
  
  巻: 8
- 査読あり / オープンアクセス
[雑誌論文] Exploring a method for extracting concerns of multiple breast cancer patients in the domain of patient narratives using BERT and its optimization by domain adaptation using masked language modeling2024
- 著者名
  Watabe S, Watanabe T, Yada S, Aramaki E, Yajima H, Kizaki H, Hori S
- 雑誌名
  
  PLOS ONE
  
  巻: 19 号: 9
- 査読あり / オープンアクセス
[雑誌論文] Utility analysis and demonstration of real-world clinical texts: A case study on Japanese cancer-related EHRs2024
- 著者名
  Shuntaro Yada, Tomohiro Nishiyama, Shoko Wakamiya, Yoshimasa Kawazoe, Shungo Imai, Satoko Hori, Eiji Aramaki
- 雑誌名
  
  PLOS ONE
- 査読あり / オープンアクセス
[雑誌論文] Association between gastroprotective agents and acute kidney injury in patients receiving non-steroidal anti-inflammatory drugs: Analysis of a Japanese hospital-based database.2024
- 著者名
  Mitsuboshi S, Imai S, Kizaki H, Hori S
- 雑誌名
  
  Pharmacotherapy
  
  巻: 44 号: 11 ページ: 851-860
- 査読あり / オープンアクセス
[雑誌論文] Uncovering condition information loss in medical text extraction: The challenge of non-contiguous spans2024
- 著者名
  Shinohara E, Shimamoto K, Kawazoe Y
- 雑誌名
  
  Next Research
  
  巻: 1 号: 2
- 査読あり / オープンアクセス
[雑誌論文] Post-marketing surveillance of anticancer drugs using natural language processing of electronic medical records2024
- 著者名
  Kawazoe Y, Shimamoto K, Seki T, Tsuchiya M, Shinohara E, Yada S, Wakamiya S, Imai S, Hori S, Aramaki E
- 雑誌名
  
  NPJ Digit Med.
  
  巻: 7
- 査読あり / オープンアクセス
[雑誌論文] Exploration of factors affecting denosumab-induced hypocalcemia in male patients with osteoporosis using a hospital-based administrative claims database2024
- 著者名
  Yuto Kamimura, Keisuke Ikegami, Hayato Kizaki, Shungo Imai, Satoko Hori
- 雑誌名
  
  Maturitas
  
  巻: 193 ページ: 108190-108190
- 査読あり / オープンアクセス
[雑誌論文] Evaluating and Enhancing Japanese Large Language Models for Genetic Counseling Support: Comparative Study of Domain Adaptation and the Development of an Expert-Evaluated Dataset2024
- 著者名
  Takuya Fukushima, Masae Manabe, Shuntaro Yada, Shoko Wakamiya, Akiko Yoshida, Yusaku Urakawa, Akiko Maeda, Shigeyuki Kan, Masayo Takahashi, Eiji Aramaki
- 雑誌名
  
  JMIR Medical Informatics
- 査読あり / オープンアクセス
[雑誌論文] Factors Affecting Delayed Recovery from Neutropenia in Patients with Pancreatic Cancer Receiving Gemcitabine plus Nab-Paclitaxel2024
- 著者名
  Yoshida N., Imai S., Kawakami K., Yokokawa T., Nakamura M., Aoyama T., Shimizu H., Naito R., Teramae M., Tsuchiya M., Kizaki H., Ozaka M., Sasahira N., Yamaguchi M., Hori S.
- 雑誌名
  
  J Cancer
  
  巻: 16 号: 5 ページ: 1413-1419
- 査読あり / オープンアクセス
[雑誌論文] Natural language processing of electronic medical records identifies cardioprotective agents for anthracycline induced cardiotoxicity2024
- 著者名
  Kawazoe Y, Tsuchiya M, Shimamoto K, Seki T, Shinohara E, Yada S, Wakamiya S, Imai S, Aramaki E, Hori S
- 雑誌名
  
  Sci Rep.
  
  巻: 15
- 査読あり / オープンアクセス
[雑誌論文] Identifying Adverse Events in Outpatients With Prostate Cancer Using Pharmaceutical Care Records in Community Pharmacies: Application of Named Entity Recognition2024
- 著者名
  Yanagisawa Y., Watabe S., Yokoyama S., Sayama K., Kizaki H., Tsuchiya M., Imai S., Someya M., Taniguchi R., Yada S., Aramaki E., Hori S.
- 雑誌名
  
  JMIR Cancer
  
  巻: 11
- 査読あり / オープンアクセス

リアルワールドテキスト処理の深化によるデータ駆動型探薬

研究代表者

荒牧 英治 奈良先端科学技術大学院大学, 先端科学技術研究科, 教授

主な研究成果

[雑誌論文] Evaluation of deep learning models for adverse event signal detection using patients’ concerns in pharmaceutical care records.2024

著者名

雑誌名

[雑誌論文] A cross-sectional survey of hepatitis B virus screening in patients who received immunosuppressive therapy for rheumatoid arthritis in Japan.2024

著者名

雑誌名

[雑誌論文] Using the natural language processing system MedNER-J to analyze pharmaceutical care records2024

著者名

雑誌名

[雑誌論文] Differing Content and Language Based on Poster-Patient Relationships on the Chinese Social Media Platform Weibo: Text Classification, Sentiment Analysis, and Topic Modeling of Posts on Breast Cancer2024

著者名

雑誌名

[雑誌論文] Concomitant use of lansoprazole and ceftriaxone is associated with an increased risk of ventricular arrhythmias and cardiac arrest in a large Japanese hospital database.2024

著者名

雑誌名

[雑誌論文] Is Boundary Annotation Necessary? Evaluating Boundary-Free Approaches to Improve Clinical Named Entity Annotation Efficiency: Case Study2024

著者名

雑誌名

[雑誌論文] External Validation and Update of the Risk Prediction Model for Denosumab-Induced Hypocalcemia Developed From a Hospital-Based Administrative Database.2024

著者名

雑誌名

[雑誌論文] Exploring a method for extracting concerns of multiple breast cancer patients in the domain of patient narratives using BERT and its optimization by domain adaptation using masked language modeling2024

著者名

雑誌名

[雑誌論文] Utility analysis and demonstration of real-world clinical texts: A case study on Japanese cancer-related EHRs2024

著者名

雑誌名

[雑誌論文] Association between gastroprotective agents and acute kidney injury in patients receiving non-steroidal anti-inflammatory drugs: Analysis of a Japanese hospital-based database.2024

著者名

雑誌名

[雑誌論文] Uncovering condition information loss in medical text extraction: The challenge of non-contiguous spans2024

著者名

雑誌名

[雑誌論文] Post-marketing surveillance of anticancer drugs using natural language processing of electronic medical records2024

著者名

雑誌名

[雑誌論文] Exploration of factors affecting denosumab-induced hypocalcemia in male patients with osteoporosis using a hospital-based administrative claims database2024

著者名

雑誌名

[雑誌論文] Evaluating and Enhancing Japanese Large Language Models for Genetic Counseling Support: Comparative Study of Domain Adaptation and the Development of an Expert-Evaluated Dataset2024

著者名

雑誌名

[雑誌論文] Factors Affecting Delayed Recovery from Neutropenia in Patients with Pancreatic Cancer Receiving Gemcitabine plus Nab-Paclitaxel2024

著者名

雑誌名

[雑誌論文] Natural language processing of electronic medical records identifies cardioprotective agents for anthracycline induced cardiotoxicity2024

著者名

雑誌名

[雑誌論文] Identifying Adverse Events in Outpatients With Prostate Cancer Using Pharmaceutical Care Records in Community Pharmacies: Application of Named Entity Recognition2024

著者名

雑誌名

荒牧英治奈良先端科学技術大学院大学, 先端科学技術研究科, 教授