「ルイス酸-外部刺激」系によるイオン性中間体の活性化

研究課題

体系的番号	JPMJCR20R3
DOI	https://doi.org/10.52926/JPMJCR20R3
研究代表者	安田誠大阪大学, 大学院工学研究科, 教授
研究期間 (年度)	2020 – 2025
概要	カゴ型金属ルイス酸に光照射や電解を加え緻密な性状制御を行い、多糖の選択的合成法を確立する。また、ルイス酸配位子の光励起によるエキシマー発生に誘起される構造変化を活用した、選択的なテルペノイドの環化を行う。ルイス酸-可視光Photoredox触媒の融合型化合物を創成し、高効率電子移動型触媒反応開発する。さらに、ルイス酸により発生する活性中間体に対するマイクロ波の非熱的効果による位置選択的反応を行う。
研究領域	新たな生産プロセス構築のための電子やイオン等の能動的制御による革新的反応技術の創出

主な研究成果
(21件)

すべて 2024

すべて雑誌論文 (21件) (国際共著 3件、査読あり 21件、オープンアクセス 11件)

[雑誌論文] Designing Local Microwave Heating of Metal Nanoparticles/Metal Oxide Substrate Composites2024
- 著者名
  Ano, Taishi and Tsubaki, Shuntaro and Fujii, Satoshi and Wada, Yuji
- 雑誌名
  
  Journal of Physical Chemistry C
  
  巻: 125 号: 43
- 査読あり
[雑誌論文] Determining the influence of microwave-induced thermal unevenness on vanadium oxide catalyst particles2024
- 著者名
  Tsubaki, Shuntaro and Matsuzawa, Tomoki and Higuchi, Tomoki and Fujii, Satoshi and Wada, Yuji
- 雑誌名
  
  Chemical Engineering Journal
  
  巻: 433
- 査読あり
[雑誌論文] Microwave-enhanced catalytic conversion of fatty acid ester to olefins by Na-ZSM-52024
- 著者名
  Ota, Shunsuke and Fukushima, Jun and Kimijima, Ken'ichi and Kimura, Masao and Igura, Noriyuki and Tezuka, Noriyasu and Sato, Takashi and Einaga, Hisahiro and Tsubaki, Shuntaro
- 雑誌名
  
  Chemical Engineering Journal
  
  巻: 497
- 査読あり
[雑誌論文] Efficient Cellobiose Hydrolysis over a Sulfonated Carbon Catalyst in a Spatially Separated Microwave Electric- and Magnetic-Field Flow Reactor2024
- 著者名
  Tsubaki, Shuntaro and Senda, Kazuaki and Onda, Ayumu and Fujii, Satoshi
- 雑誌名
  
  ACS Sustainable Chemistry and Engineering
  
  巻: 12 号: 52
- 査読あり
[雑誌論文] Selective recognition between aromatics and aliphatics by cage-shaped borates supported by a machine learning approach2024
- 著者名
  Yuya Tsutsui, Issei Yanaka, Kazuhiro Takeda, Masaru Kondo, Shinobu Takizawa, Ryosuke Kojima, Akihito Konishi, Makoto Yasuda
- 雑誌名
  
  Organic & Biomolecular Chemistry
  
  巻: 22 号: 21 ページ: 4283-4291
- 査読あり
[雑誌論文] Chemical synthesis of Acetobacter pasteurianus lipid A with a unique tetrasaccharide backbone and evaluation of its?immunological functions.2024
- 著者名
  Haruki Yamaura, Atsushi Shimoyama, Koji Hosomi, Kazuya Kabayama, Jun Kunisawa, Koichi Fukase
- 雑誌名
  
  Angewandte Chemie (International ed. in English)
- 査読あり / オープンアクセス
[雑誌論文] Preclinical Evaluation of Biodistribution and Toxicity of [211At]PSMA-5 in Mice and Primates for the Targeted Alpha Therapy against Prostate Cancer.2024
- 著者名
  Tadashi Watabe, Kazuko Kaneda-Nakashima, Yuichiro Kadonaga, Kazuhiro Ooe, Thosapol Sampunta, Naoki Hirose, Xiaojie Yin, Hiromitsu Haba, Yukiyoshi Kon, Atsushi Toyoshima, Jens Cardinale, Frederik L Giesel, Koichi Fukase, Noriyuki Tomiyama, Yoshifumi Shirakami
- 雑誌名
  
  International journal of molecular sciences
  
  巻: 25 号: 11
- 査読あり / オープンアクセス
[雑誌論文] Systematic Strategy for the Development of Glycosyltransferase Inhibitors: Diversity-Oriented Synthesis of FUT8 Inhibitors2024
- 著者名
  Yoshiyuki Manabe, Koki Hizume, Yohei Takakura, Shinji Takamatsu, Eiji Miyoshi, Yoshihiro Kamada, Ramon Hurtado-Guerrero, Koichi Fukase
- 雑誌名
  
  Synlett
  
  巻: 35 号: 11 ページ: 1273-1278
- 査読あり / 国際共著
[雑誌論文] <i>De Novo</i> Glycan Display on Cell Surfaces Using HaloTag: Visualizing the Effect of the Galectin Lattice on the Lateral Diffusion and Extracellular Vesicle Loading of Glycosylated Membrane Proteins2024
- 著者名
  Ayane Miura, Yoshiyuki Manabe, Kenichi G. N. Suzuki, Hiroki Shomura, Soichiro Okamura, Asuka Shirakawa, Kumpei Yano, Shuto Miyake, Koki Mayusumi, Chun-Cheng Lin, Kenta Morimoto, Jojiro Ishitobi, Ikuhiko Nakase, Kenta Arai, Shouhei Kobayashi, Ushio Ishikawa, Hirotaka Kanoh, Eiji Miyoshi, Toshiyuki Yamaji, Kazuya Kabayama, Koichi Fukase
- 雑誌名
  
  Journal of the American Chemical Society
- 査読あり / 国際共著
[雑誌論文] Photo-induced glycosylation using the edible polyphenol curcumin.2024
- 著者名
  Satomi Goi, Hidenari Shigeta, Daisuke Takahashi, Kazunobu Toshima
- 雑誌名
  
  Organic & Biomolecular Chemistry
  
  巻: 22 号: 27 ページ: 5546-5551
- 査読あり
[雑誌論文] Designed Mannosylerythritol Lipid Analogues Exhibiting Both Selective Cytotoxicity Against Human Skin Cancer Cells and Recovery Effects on Damaged Skin Cells.2024
- 著者名
  Jikun Meng, Chihiro Yasui, Mai Shida, Kazunobu Toshima, Daisuke Takahashi
- 雑誌名
  
  Chemistry-A European Journal
  
  巻: 30 号: 48
- 査読あり / オープンアクセス
[雑誌論文] Development of a FUT8 Inhibitor with Cellular Inhibitory Properties2024
- 著者名
  Yoshiyuki Manabe, Tomoyuki Takebe, Satomi Kasahara, Koki Hizume, Kazuya Kabayama, Yoshihiro Kamada, Akiko Asakura, Shinichiro Shinzaki, Shinji Takamatsu, Eiji Miyoshi, Ana Garcia-Garcia, Sergey Y. Vakhrushev, Ramon Hurtado-Guerrero, Koichi Fukase
- 雑誌名
  
  Angewandte Chemie International Edition
- 査読あり / オープンアクセス / 国際共著
[雑誌論文] Synthesis of Low-Molecular-Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS-CoV-2 Infection.2024
- 著者名
  Aoi Sugimoto, Tatsuki Koike, Yuya Kuboki, Sumika Komaba, Shuhei Kosono, Maniyamma Aswathy, Itsuki Anzai, Tokiko Watanabe, Kazunobu Toshima, Daisuke Takahashi
- 雑誌名
  
  Angewandte Chemie - International Edition
- 査読あり / オープンアクセス
[雑誌論文] Cage-Shaped Borate Catalysts Bearing Precisely Controlled Lewis Acidity and Their Application in Glycosylations2024
- 著者名
  Yoshiyuki Manabe, Yuya Tsutsui, Yosuke Tanaka, Yuka Yokoyama, Yuka Ikinaga, Tatsuya Nishitani, Kumpei Yano, Ryohei Miyagawa, Koichi Fukase, Akihito Konishi, Makoto Yasuda
- 雑誌名
  
  The Journal of Organic Chemistry
  
  巻: 89 号: 21 ページ: 15630-15635
- 査読あり
[雑誌論文] Comparison Length of Linker in Compound for Nuclear Medicine Targeting Fibroblast Activation Protein as Molecular Target.2024
- 著者名
  Kentaro Hisada, Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Yuichiro Kadonaga, Atsuko Saito, Tadashi Watabe, Sifan Feng, Kazuhiro Ooe, Xiaojie Yin, Hiromitsu Haba, Masashi Murakami, Atsushi Toyoshima, Jens Cardinale, Frederik L Giesel, Koichi Fukase
- 雑誌名
  
  International journal of molecular sciences
  
  巻: 25 号: 22
- 査読あり / オープンアクセス
[雑誌論文] Development of LAT1-Selective Nuclear Medicine Therapeutics Using Astatine-2112024
- 著者名
  Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Kentaro Hisada, Sifan Feng, Yuichiro Kadonaga, Kazuhiro Ooe, Tadashi Watabe, Yoshiyuki Manabe, Atsushi Shimoyama, Masashi Murakami, Atsushi Toyoshima, Hiromitsu Haba, Yoshikatsu Kanai, Koichi Fukase
- 雑誌名
  
  International Journal of Molecular Sciences
  
  巻: 25 号: 22 ページ: 12386-12386
- 査読あり / オープンアクセス
[雑誌論文] Toward Multi‐Functionalized Organogermaniums: Diastereoselective Transformations of Germacycles Derived from Cheletropic Reactions of Boron‐Substituted Butadienes with Ge(II) Salts2024
- 著者名
  Taishi Nojima, Yugo Izumi, Akihito Konishi, Makoto Yasuda
- 雑誌名
  
  European Journal of Organic Chemistry
  
  巻: 27
- 査読あり / オープンアクセス
[雑誌論文] Synthesis and Characterization of Quinoxaline-Fused Cyclopenta[cd]azulene2024
- 著者名
  Tomohiro Oda, Yuina Onishi, Akihito Konishi, Makoto Yasuda
- 雑誌名
  
  Chemistry
  
  巻: 7 号: 1 ページ: 15-15
- 査読あり / オープンアクセス
[雑誌論文] Creation of a macrolide antibiotic against non-tuberculous <i>Mycobacterium</i> using late-stage boron-mediated aglycon delivery2024
- 著者名
  Yuka Isozaki, Takumi Makikawa, Kosuke Kimura, Daiki Nishihara, Maho Fujino, Yoshikazu Tanaka, Chigusa Hayashi, Yoshimasa Ishizaki, Masayuki Igarashi, Takeshi Yokoyama, Kazunobu Toshima, Daisuke Takahashi
- 雑誌名
  
  Science Advances
  
  巻: 11 号: 10
- 査読あり / オープンアクセス
[雑誌論文] Photo-induced glycosylation using edible polyphenol ellagic acid2024
- 著者名
  Hidenari Shigeta, Satomi Goi, Daisuke Takahashi, Kazunobu Toshima
- 雑誌名
  
  Carbohydrate Research
  
  巻: 552 ページ: 109461-109461
- 査読あり
[雑誌論文] Multiple Near‐Infrared Chromisms of a Heteromerous Overcrowded Ethylene with Large Permanent Dipole Moment2024
- 著者名
  Akihiro Shimizu, Yuki Misaki, Chihiro Kondo, Ayane Kayama, Takashi Hirose, Hiroyasu Sato, Ryo Shintani
- 雑誌名
  
  Angewandte Chemie International Edition
- 査読あり / オープンアクセス

「ルイス酸-外部刺激」系によるイオン性中間体の活性化

研究代表者

安田 誠 大阪大学, 大学院工学研究科, 教授

主な研究成果

[雑誌論文] Designing Local Microwave Heating of Metal Nanoparticles/Metal Oxide Substrate Composites2024

著者名

雑誌名

[雑誌論文] Determining the influence of microwave-induced thermal unevenness on vanadium oxide catalyst particles2024

著者名

雑誌名

[雑誌論文] Microwave-enhanced catalytic conversion of fatty acid ester to olefins by Na-ZSM-52024

著者名

雑誌名

[雑誌論文] Efficient Cellobiose Hydrolysis over a Sulfonated Carbon Catalyst in a Spatially Separated Microwave Electric- and Magnetic-Field Flow Reactor2024

著者名

雑誌名

[雑誌論文] Selective recognition between aromatics and aliphatics by cage-shaped borates supported by a machine learning approach2024

著者名

雑誌名

[雑誌論文] Chemical synthesis of Acetobacter pasteurianus lipid A with a unique tetrasaccharide backbone and evaluation of its?immunological functions.2024

著者名

雑誌名

[雑誌論文] Preclinical Evaluation of Biodistribution and Toxicity of [211At]PSMA-5 in Mice and Primates for the Targeted Alpha Therapy against Prostate Cancer.2024

著者名

雑誌名

[雑誌論文] Systematic Strategy for the Development of Glycosyltransferase Inhibitors: Diversity-Oriented Synthesis of FUT8 Inhibitors2024

著者名

雑誌名

[雑誌論文] <i>De Novo</i> Glycan Display on Cell Surfaces Using HaloTag: Visualizing the Effect of the Galectin Lattice on the Lateral Diffusion and Extracellular Vesicle Loading of Glycosylated Membrane Proteins2024

著者名

雑誌名

[雑誌論文] Photo-induced glycosylation using the edible polyphenol curcumin.2024

著者名

雑誌名

[雑誌論文] Designed Mannosylerythritol Lipid Analogues Exhibiting Both Selective Cytotoxicity Against Human Skin Cancer Cells and Recovery Effects on Damaged Skin Cells.2024

著者名

雑誌名

[雑誌論文] Development of a FUT8 Inhibitor with Cellular Inhibitory Properties2024

著者名

雑誌名

[雑誌論文] Synthesis of Low-Molecular-Weight Fucoidan Analogue and Its Inhibitory Activities against Heparanase and SARS-CoV-2 Infection.2024

著者名

雑誌名

[雑誌論文] Cage-Shaped Borate Catalysts Bearing Precisely Controlled Lewis Acidity and Their Application in Glycosylations2024

著者名

雑誌名

[雑誌論文] Comparison Length of Linker in Compound for Nuclear Medicine Targeting Fibroblast Activation Protein as Molecular Target.2024

著者名

雑誌名

[雑誌論文] Development of LAT1-Selective Nuclear Medicine Therapeutics Using Astatine-2112024

著者名

雑誌名

[雑誌論文] Toward Multi‐Functionalized Organogermaniums: Diastereoselective Transformations of Germacycles Derived from Cheletropic Reactions of Boron‐Substituted Butadienes with Ge(II) Salts2024

著者名

雑誌名

[雑誌論文] Synthesis and Characterization of Quinoxaline-Fused Cyclopenta[cd]azulene2024

著者名

雑誌名

[雑誌論文] Creation of a macrolide antibiotic against non-tuberculous <i>Mycobacterium</i> using late-stage boron-mediated aglycon delivery2024

著者名

雑誌名

[雑誌論文] Photo-induced glycosylation using edible polyphenol ellagic acid2024

著者名

雑誌名

[雑誌論文] Multiple Near‐Infrared Chromisms of a Heteromerous Overcrowded Ethylene with Large Permanent Dipole Moment2024

著者名

雑誌名

安田誠大阪大学, 大学院工学研究科, 教授